Drug resistance remains an important factor affecting the efficacy of HIV antiretroviral therapy.Integrase inhibitors have attracted more attention due to their higher genetic resistance barriers and longer half-lives.However,reports of drug resistance have emerged in various regions following the unremitting promotion and use of integrase inhibitors.Relevant research has shown that different strain subtypes have varying resistance mutation sites,which challenges the therapeutic efficacy of integrase inhibitors.Therefore,the study of integrase inhibitor resistance has become an unavoidable issue in antiviral therapy.This paper reviews the types and applications of integrase inhibitors,the prevalence of integrase inhibitor resistance both domestically and internationally,the differences in drug sensitivity caused by different subtypes of resistance mutation sites,and the challenges and prospects of integrase inhibitors currently.
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