摘要
HIV与结核分枝杆菌(MTB)共感染是全球性重要的公共卫生问题.HIV-MTB共感染的诊断较单纯MTB感染更困难,二者相互影响,治疗上涉及抗HIV和抗MTB治疗两个方面,加之药物间相互作用、不良反应及耐药性等均会影响治疗效果,治疗成功率较低.本文从HIV-MTB共感染的危害、一般治疗、抗结核治疗、抗病毒治疗、免疫治疗、外科治疗等方面的最新进展加以综述,为HIV-MTB共感染的综合治疗提供参考.
Abstract
Co-infection of HIV and Mycobacterium tuberculosis(MTB)is a significant global public health issue.Diagnosing HIV/MTB co-infection is more challenging than diagnosing MTB simplex infection,due to the interaction between the two viruses.Successful treatment requires a combination treatments of anti-HIV and anti-MTB,as well as taking into account drug interactions,adverse reactions,and drug resistance.The success rate of treatment is relatively low.This article provides a comprehensive review of the latest progress on treatment of HIV-MTB co-infection,which covers harm reduction,general treatment,anti-tuberculosis treatment,antiviral treatment,immune therapy,surgical treatment,and other relevant aspects.The aim is to provide a useful reference for the comprehensive treatment of HIV-MTB co-infection.
基金项目
"十三五"国家科技重大专项(2017ZX10202101-001-006)
"十三五"国家科技重大专项(2018ZX10715-008-002)
上海市科委医学创新研究专项重大项目(21Y31900400)
维普
万方数据