摘要
目的 通过数据挖掘全面总结中医药治疗HIV/AIDS患者免疫重建不良的用药规律,系统分析核心药物.方法 检索中英文文献数据库(中国知网、万方数据库、维普数据库、PubMed数据库、Cochrane图书馆等)中关于中医药治疗免疫重建不良的文献资料,根据纳入与排除标准筛选文献,对纳入文献进行数据收集、录入,对药物名称进行规范化处理,并运用频数分布分析、药物性味归经分析、关联规则分析以及聚类分析等方法对数据进行全面分析.结果 共纳入26篇相关文献,获得54味中药,用药总频次为150次,使用频次较高的中药为黄芪、白术、党参、灵芝、五味子、茯苓、甘草、人参、枸杞子、菟丝子.高频药物性味以甘平为主,归经以肺经、脾经、肾经为主,关联规则分析结果显示黄芪、白术、党参为核心药物,黄芪与白术、党参、茯苓、枸杞子等药物关联度较高.聚类分析后获得3首潜在核心方剂,分别为C1:人参、茯苓、白术、甘草;C2:枸杞子、菟丝子、五味子;C3:党参、灵芝、黄芪.结论 中医药治疗免疫重建不良多以甘平药物为主,通过调补肺脾、温肾助阳而发挥促进免疫重建之效.
Abstract
Objective To comprehensively summarize the medication rules of traditional Chinese medicine(TCM)for the treatment of immunological non-responders through data mining,and to systematically analyze the core medicines.Methods A literature review was conducted using both Chinese and English databases,including China National Knowledge Internet(CNKI),Wanfang Data Knowledge Service Platform,VIP Chinese Journal Service Platform,PubMed,and Cochrane Library,to collect relevant literature on TCM treatment for immunological non-responders.According to strict inclusion and exclusion criteria,the collected literatures were screened and recorded,and medication names were standardized.Frequency distribution analysis,analysis of the meridian tropism with properties,and tastes,association rules analysis,and cluster analysis were employed to comprehensively analyze the data.Results A total of 26 relevant literatures were included,and 54 Chinese herbs were identified.The most frequently used TCM herbs were Astragalus,Atractylodes,Codonopsis,Reishi,Schisandra,Poria,Licorice,Panax ginseng,Goji berries,and Semen Cuscutae,with a total medication use frequency of 150.The majority of high-frequency medications exhibited a sweet and neutral nature,primarily targeting the Lung,Spleen,and Kidney meridians.Association rule analysis revealed that Astragalus,Atractylodes,and Codonopsis were the core medications.And Astragalus exhibited a strong association with Atractylodes,Codonopsis,Poria,and Goji berries.After clustering analysis,three potential core formulas were obtained:Cl:Panax ginseng,Poria,Atractylodes,Licorice;C2:Goji berries,Semen Cuscutae,Schisandra;C3:Codonopsis,Reishi,Astragalus.Conclusions TCM treatment for immunological non-responders primarily relies on sweet and neutral medications.The therapy of tonifying the lungs and spleen,and warming the kidney-yang can promote immune reconstitution.
基金项目
国家科技重大专项(十三五)(2017ZX10205501)
传染病防治重大专项结余经费再立项项目(2022021)
NETL
NSTL
万方数据