Research Progress on the role of cellular autophagy in anti-HIV-1 infection
Cellular autophagy maintains homeostasis of the intracellular environment by degrading damaged organelles,excess proteins,and other cytoplasmic components.It exists in a variety of disease models,including infectious diseases.Autophagy serves as a natural antiviral mechanism against invading viruses,while viruses have also evolved anti-autophagy strategies to evade clearance.Given the biphasic and complex antiviral effects of autophagy,this article reviews the research progress on autophagy,its antiviral mechanisms,and the impact of autophagy on HIV-1 infection,providing new therapeutic targets and research directions for autophagy-based anti-HIV-1 infection.
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