Research progress on the roles and molecular mechanisms of inflammasomes in HIV infection
HIV is a lentivirus.Although antiviral therapy(ART)and other therapies are currently effective in suppressing viral replication,they cannot completely control the latent infection of the virus or the abortive infection of the virus fragments,resulting in the possibility of further replication and spread of HIV,as well as the generation of CASP1-dependent pyroptosis.Inflammasomes play an important role in HIV-induced pyroptosis,and targeting the inflammasomes to regulate immune balance is a major focus for controlling the progression of HIV infection and treating HIV.In recent years,the role and molecular mechanisms of three inflammasomes,NLRP3,CARD8,and IFI16,in HIV infection have been studied in-depth.This article summarizes the relationship between inflammasomes and HIV infection,and discusses their antiviral and pro-inflammatory bidirectional effects and related mechanisms.
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