HCV antibody positivity rates among injection and non-injection drug users in China from 2010 to 2020:a meta-analysis
Objective A meta-analysis was conducted to provide the prevalence of hepatitis C virus(HCV)antibody(anti-HCV)positivity among injection drug users(IDUs)and non-injection drug users(non-IDUs)in China,offering scientific evidence for the prevention and treatment of these populations with hepatitis C.Methods A systematic retrieval was conducted for literature published between January 1,2010,and October 1,2023,in databases including PubMed,Web of Science,Embase,Scopus,China National Knowledge Internet(CNKI),Wanfang Data Knowledge Service Platform and SinoMed that reported on the anti-HCV positivity rates among IDUs and non-IDUs in China.Relevant literature was screened,assessed,and data were extracted.Statistical analysis was performed using RStudio 4.1.0.Subgroup analyses were applied by region,source,and study year.Publication bias was evaluated using the Egger's test.Results A total of 38 articles were included,covering 23 provinces(autonomous regions and municipalities)with sample sizes of 37 053 IDUs and 60 689 non-IDUs.The meta-analysis showed that from 2010 to 2020,the anti-HCV positivity rates were significantly higher among IDUs(66.9％,95％CI:59.0％-74.3％)than non-IDUs(20.4％,95％CI:15.3％-26.0％)(P＜0.05).The highest prevalence rates for both IDUs and non-IDUs were in the southwestern regions,with 82.5％and 32.2％,respectively;while the lowest were in central China,with 40.2％and 8.8％,respectively.No significant difference was found in the anti-HCV positivity rates among different sources of studies and between different years for both IDUs and non-IDUs(P＞0.05).Conclusions The high anti-HCV positivity rates among IDUs and non-IDUs in China indicate a need for measures to reduce HCV transmission,improve the detection and treatment rates of HCV infection,and decrease the burden of hepatitis C disease in these groups.
hepatitis cinjection drug users(IDUs)non-injection drug users(non-IDUs)hepatitis C virus(HCV)antibody(anti-HCV)meta-analysis
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