Objective To investigate the situation on perinatal mortality of pregnant women infected with syphilis and its influencing factors,and to provide a reference for reducing the level of perinatal deaths and eliminating the mother-to-child transmission in Hubei Province.Methods Epidemiological survey data on syphilis-infected pregnant women who gave birth in Hubei Province in the National Management Information System for the Prevention of Mother-to-Child Transmission of Syphilis(NPMTCT)from January 1,2012 to December 31,2021,were collected.The Chi-square test for trend and logistic regression methods were used to analyze the perinatal mortality of syphilis-infected pregnant women and the influencing factors.Results From 2012 to 2021,the perinatal mortality of pregnant women with syphilis in Hubei Province decreased significantly from 39.11％o(7/179)to 5.57％o(3/539)(x2trend=9.95,P=0.002).The mortality of perinatal infants born to syphilis-infected pregnant women was higher than that of the whole population.The results of multivariate analysis results indicated that a titer of ≥1:8 in the last pregnant serological tests for non-syphilis(OR=5.58,95％CI:2.02-15.36),or an unknown titer(OR=4.52,95％CI:1.70-12.02),as well as preterm birth or low birth weight(OR=7.21,95％CI:4.72-11.03),neonatal asphyxia(OR=16.82,95％CI:8.10-34.93),birth defects(OR=11.52,95％CI:5.09-26.10)were all risk factors for perinatal death in pregnant women with syphilis infection(P＜0.05),while receiving treatments(OR=0.58,95％CI:0.37-0.91)was identified as a protective factor against perinatal death in syphilitic-infected pregnant women.Conclusions The mortality of perinatal infants born to pregnant women with syphilis in Hubei Province shows a decreasing trend year by year,and preterm birth/low birth weight is the primary cause of perinatal mortality of pregnant women with syphilis.Emphasis on carrying out publicity and education,early detection and standardized treatment,reducing serological tests for non-syphilis,and strengthening the quality of neonatal health care service are important means to reduce the risk of perinatal mortality.
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