目的 基于CiteSpace对国内外HIV/AIDS患者血脂异常的研究现状、热点和趋势进行可视化分析,探索未来研究方向.方法 检索建库至2023年9月15日Web of Science核心合集(WOS)和中国知网(CNKI)中HIV/AIDS患者血脂异常的相关文献,借助CiteSpace对文献进行可视化分析.结果 共纳入中文文献105篇、英文文献525篇.近年国内发文量持续增长,国外发文量有所回落,但仍高于国内.发文量最多的国家为美国(226篇),中国排名第5(27篇);国外发文量最多的机构为哈佛大学,国内为河南中医药大学;排名前3位的中文高频关键词为血脂异常、艾滋病、高效抗反转录病毒治疗,英文高频关键词为血脂异常、心血管疾病、抗反转录病毒治疗;关键词聚类分析获得8个聚类.结论 目前HIV感染合并血脂异常领域的研究热点主要包括影响因素、心血管疾病、患病率、高效抗反转录病毒治疗、蛋白酶抑制剂等.研究方向主要包括:不同抗病毒药物对血脂的影响研究、HIV/AIDS患者血脂异常现状及影响因素研究、抗病毒药物和降血脂药物作用机制及疗效研究等.国内HIV感染合并血脂异常领域还有较大研究空间,后续应开展更多高质量研究.未来可对中医治疗、饮食、运动及其他影响因素干预对血脂的影响做进一步探索.
Visual analysis of research hotpots in dyslipidemia among patients with HIV/AIDS based on CiteSpace
Objective To perform a visual analysis of the current research status,hotspots,and trends of dyslipidemia among patients with HIV/AIDS in China and abroad based on the CiteSpace software,and to explore future development directions.Methods Literature related to dyslipidemia among patients with HIV/AIDS published between database creation and September 15,2023,was retrieved from the core collections of Web of Science and China National Knowledge Infrastructure and visually analyzed through the CiteSpace 6.1.R6 software.Results A total of 105 studies published in Chinese and 525 in English were included.In recent years,the number of domestic publications has continued to increase,while the number of foreign publications has declined;nonetheless,the number of foreign publications was still higher than that of the domestic publications.The country with the highest number of publications was the United States(226 articles)while China ranked 5th(27 articles).The institution with the highest number of publications was Harvard University abroad and Henan University of Traditional Chinese Medicine in China.The top three Chinese high-frequency keywords were dyslipidemia,AIDS,and highly active antiretroviral therapy,while the English high-frequency keywords were dyslipidemia,cardiovascular disease,and antiretroviral therapy.Keyword cluster analysis yielded 8 clusters.Conclusions The current research hotpots in the field of HIV/AIDS combined with dyslipidemia mainly included risk factors,cardiovascular disease,prevalence,highly active antiretroviral therapy,and protease inhibitors.The research directions mainly comprise the effects of different antiviral drugs on blood lipids,current status and influencing factors of dyslipidemia in patients with HIV/AIDS,and the mechanism and efficacy of antiviral and lipid-lowering drugs.A significant research gap exists in the field of HIV/AIDS and dyslipidemia within China,warranting further high-quality studies.Future investigations could focus on the effects of traditional Chinese medicine,dietary habits,physical activity,and additional factors on blood lipid levels.
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