HIV-encoded proteins,including the matrix protein p17,glycoprotein gp120,reverse transcriptase,Tat,and Nef,play extensive roles in the proliferation and metastasis of tumor cells and are closely associated with the formation of the tumor microenvironment.In recent years,there has been significant progress in understanding how HIV-encoded proteins influence tumor initiation,progression,and the underlying regulatory mechanisms in individuals infected with HIV.This article provides a comprehensive review of the regulatory mechanisms exerted by HIV-encoded proteins on HIV-associated tumors.
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