Prevalence and influencing factors of non-alcoholic fatty liver disease in na?ve patients with HIV/AIDS from 2022 to 2023
Objective To investigate the prevalence of non-alcoholic fatty liver disease(NAFLD)and its influencing factors in treatment-naïve patients with HIV/AIDS at the Second Hospital of Nanjing.Methods The prevalence of NAFLD among treatment-naïve outpatients with HIV/AIDS from 1 June 2022 to 30 September 2023 was calculated,and the factors influencing NAFLD were analyzed.SPSS 26.0 software was used for chi-square test,rank sum tests,and Logistic regression analysis.Results A total of 420 patients were investigated,of whom 125 were diagnosed with NAFLD,resulting in an overall prevalence of 29.8％.Multivariate Logistic regression analysis showed that,TG≥1.7 mmol/L(OR=2.247,95％CI:1.305-3.871,P=0.004),HDL-C＜1.04 mmol/L(OR=1.658,95％CI:1.007-2.731,P=0.047),and hepatic steatosis index(HSI)≥36.0(OR=4.761,95％CI:2.176-10.417,P＜0.001)as risk factors for NAFLD in treatment-naïve patients with HIV/AIDS;while age≥40 years old(OR=0.522,95％CI:0.286-0.953,P=0.034),BMI＜18.5 kg/m2(OR=0.081,95％CI:0.011-0.610,P=0.015)were protective factors for NAFLD.Conclusions The prevalence of NAFLD among treatment-naïve patients with HIV/AIDS is comparable to that of the general population.More attention should be paid to patients with elevated TG,decreased HDL-C,and increased HSI scores,and lipid monitoring and weight management should be intensified to assess the risk of NAFLD,and implement timely interventions.
NETL
NSTL
万方数据
