The efficacy of neutrophil elastase inhibitors in the treatment of AIDS patients co-infected with acute lung injury/acute respiratory distress syndrome
Objective This study aimed to investigate the effectiveness of neutrophil elastase inhibitors(NEIs)in treating acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)in patients with AIDS.Methods A retrospective case-control study was conducted,and 83 patients co-infected with AIDS and ALI/ARDS admitted to the Kunming Third People's Hospital between January 1,2022,and December 31,2023,were included.The patients were divided into two groups:the conventional group(n=60),receiving routine treatment,and the NEI group(n=23),receiving NEI in addition to routine treatment.Data were analyzed using t-tests,chi-square tests,and Pearson correlation coefficient analysis using SPSS 26.0.Results Among the 83 patients,60 received routine treatment only(conventional group)and 23 received NEI in addition to routine treatment(NEI group).No significant differences were observed in the baseline characteristics between the two groups(P＞0.05).After treatment,the NEI group showed a higher oxygenation index(PaO2/FiO2,185.8±34.7 mmHg)and IL-10(28.7±7.5 pg/mL)compared with the conventional group(167.3±31.2 mmHg,14.9±3.5 pg/mL).The NEI group had a lower white blood cell count(9.2±2.2×109/L),C-reactive protein(9.7±3.5 mg/L),IL-6(32.5±9.8 pg/mL),and IL-8(29.0±7.1 pg/mL)compared with the conventional group(10.5±2.3×109/L,13.2±4.1 mg/L,45.6±12.3 pg/mL,and 35.3±8.4 pg/mL).In terms of treatment outcomes,the NEI group had a higher average duration of non-mechanical ventilation(10.8±3.1 days)compared with the conventional group(8.7±2.8 days)(P＜0.01).The 28-day mortality rate was lower in the NEI group(13.0％)compared with the conventional group(21.7％)(P=0.03).Pearson's correlation coefficient analysis showed that white blood cell count,C-reactive protein,IL-6,and IL-10 were positively correlated with 28-day mortality,with IL-10 having a correlation coefficient of 0.24.Conclusions NEI can effectively improve oxygenation,reduce inflammatory markers,increase anti-inflammatory factors,increase the duration of non-mechanical ventilation,and reduce 28-day mortality in patients with AIDS and ALI/ARDS.
万方数据
维普
