The timing of antiretroviral therapy initiation and influencing factors among HIV-infected individuals in Sichuan Province from 2018 to 2022
Objective This study aimed to understand the changes in the timeliness of combination antiretroviral therapy(cART)initiation among newly diagnosed patients with HIV infection in Sichuan Province from 2018 to 2022 and explore the influencing factors.Methods Newly diagnosed individuals with HIV infection recorded in the National Comprehensive HIV/AIDS Prevention and Control Information System between 2018 and 2022 were included.The observation period began on the date of diagnosis and ended on December 31,2023.A retrospective analysis examined changes in the timeliness of cART initiation,and Cox regression analysis was performed to identify the influencing factors.Results A total of 143 151 individuals were included in the analysis,with a median cART initiation time of 18 days.The median cART initiation time for each year was 36,19,15,13,and 13 days from 2018 to 2022,respectively.The proportions of individuals initiating cART on the day of diagnosis,2-7 days,8-14 days,15-30 days,31-180 days,181-365 days,and more than 365 days were 0.69％,19.27％,22.61％,22.44％,21.25％,4.39％,and 2.66％,respectively.Compared with male individuals,aged 65 or above,unmarried,illiterate or primary school educated,with heterosexual transmission,baseline CD4 cell count of less than 200 cells/μL,and those who are reported and initiated treatment within the county,those who were female,younger than 18 or between 50-65 years old,married,had different marital statuses,had an educational level of junior high school,high school,or university and above,had same-sex transmission,had higher baseline CD4+T cell counts or were not tested,and were referred from other districts within the same city had a higher probability of earlier cART initiation.Conclusions Prompt initiation of cART among newly diagnosed individuals with HIV infection in Sichuan Province improved from 2018 to 2022.Promptly initiating cART for males,unmarried individuals,those with heterosexual transmission,those with lower educational levels,healthcare workers/places proactively offering testing,individuals from ethnic minorities,those with a delayed diagnosis,and individuals with HIV infections moving across districts is recommended.
万方数据
维普
