Mechanism of Yiaikang Capsule in the treatment of AIDS based on network pharmacology
Objective This study aimed to explore the potential mechanisms of action of the Yiaikang Capsule in treating AIDS by analyzing its target proteins and signaling pathways using network pharmacology.Methods The Traditional Chinese Medicine Systems Pharmacology(TCMSP)database was used to retrieve the chemical components and corresponding targets of Yiaikang Capsules.Potential targets related to AIDS were obtained from GeneCards,Online Mendelian Inheritance in Man(OMIM),and National Center for Biotechnology Information(NCBI)Databases.The intersection targets between the Yiaikang Capsule and AIDS were obtained using Excel.A protein-protein interaction network was constructed using Cytoscape software and the STRING database platform,followed by topological analysis.GO enrichment and KEGG pathway analyses of the biological processes and metabolic pathways related to the Yiaikang Capsule for treating AIDS were performed using the DAVID database platform.Results Network pharmacology analysis identified 90 chemical components and 229 corresponding targets in the Yiaikang Capsule.There are 81 chemical components related to AIDS,including but not limited to quercetin,kaempferol,wogonin,baicalein,β-sitosterol and other key substances.There are 110 targets associated with AIDS,among which AKT1 and cytokines IL-6,TNF,TP53,CASP3 are more significant.Yiaikang Capsule may treat AIDS through biological processes,such as the negative regulation of the apoptotic process,positive regulation of gene expression,positive regulation of RNA polymerase Ⅱ promoter transcription,enzyme binding,protein binding,and protein kinase binding.Its therapeutic effects may be exerted on AIDS by modulating signaling pathways,such as IL-17,TNF,and PI3K-AKT.Conclusions This study provides a preliminary exploration of the chemical components,target pathways,and interaction relationships of the Yiaikang Capsule in AIDS treatment.It is predicted that the Yiaikang Capsule may intervene in the TNF and PI3K-AKT pathways by regulating the expression of TNF and AKT1 genes to exert its therapeutic effects on AIDS.
万方数据
维普
