Effectiveness of combined immunization time in preventing mother-to-child transmission of hepatitis B virus in Bao'an District,Shenzhen,Guangdong
Objective This study aimed to analyze the administration of the first dose of hepatitis B vaccine(HepB1)and hepatitis B immune globulin(HBIG)in children exposed to hepatitis B virus(HBV)in Bao'an District,Shenzhen.Additionally,we aimed to explore the impact of the combined immunization timing on the effectiveness of mother-to-child transmission(MTCT)blockade for hepatitis B.Methods Information on mothers infected with HBV and their children born in 18 obstetric hospitals in the Bao'an District from 2017 to 2021 was collected.Serological test results for children exposed to hepatitis B after immunization were obtained for statistical analysis.Results A total of 7 396 pairs of hepatitis B surface antigen-positive mothers and hepatitis B-exposed children were included in the study.The timely HepB1 vaccination rate increased from 77.74％in 2017 to 99.69％in 2021,and the HBIG injection rate increased from 76.62％in 2017 to 98.77％in 2021.The MTCT for hepatitis B was 0.31％,with an immunization success rate of 98.42％.Compared with the reference group(≥12 hours),the odds ratio(OR)for MTCT of hepatitis B was 0.11(95％CI:0.02-0.53)when combined immunization was implemented within 0 to＜6 hours.Maternal hepatitis B e-antigen positivity was also a risk factor for MTCT(OR=28.50,95％CI:6.55-123.97).Conclusions Early implementation of combined immunization is a protective factor against MTCT.In areas with limited availability of HBV DNA testing and antiviral treatment,consideration should be given to extremely early combined vaccination(within 6 hours after birth)for exposed children to further reduce the risk of MTCT for hepatitis B.
hepatitis B virus(HBV)hepatitis B vaccine(HepB1)hepatitis B immunoglobulin(HBIG)combined immunizationmother-to-child transmission(MTCT)
万方数据
维普
