Impact of traditional Chinese medicine on mortality among AIDS patients based on disease risk score matching
Objective This study aimed to analyze factors influencing mortality among AIDS patients who are treated with traditional Chinese medicine(TCM).Methods Utilizing data from the routine AIDS treatment database,this study focused on AIDS patients who transitioned to second-line combination antiretroviral therapy(cART)from May 2010 to May 2016,with a follow-up period of 10 years.Patients involved in the TCM project were classified as the TCM group,while those not participating were considered the non-TCM group.After matching the groups at a 1:1 ratio using the disease risk score method,the cox frailty model was applied to assess the impact of TCM on mortality.Results Of the 2 954 AIDS patients meeting the inclusion criteria,610 were matched in both the TCM and non-TCM groups,totaling 1 220 patients.At the follow-up's end,the TCM group recorded 72 cumulative deaths,with a mortality density of 1.46 per 100 person-years,whereas the non-TCM group had 105 deaths,with a mortality density of 2.10 per 100 person-years.This significant difference in mortality density(P＜0.05)highlights the potential benefit of TCM.Univariate analysis with the cox frailty model suggested a lower risk of death in the TCM group.Multivariate analysis identified several risk factors for mortality,including male gender,older age,being single or widowed,lower educational level,being HIV-positive for less than five years,low CD4+T cell count,and abnormal platelet count.Conclusions After adjusting for confounders with disease risk score matching and the cox frailty model,TCM treatment appears to significantly reduce mortality risk among AIDS patients.
AIDStraditional Chinese medicinemortalitydisease risk scorecox frailty model
万方数据
维普
