Major HIV-1 epidemic strains in the Baise region from 2022 to 2023
Objective To analyze the predominant HIV-1 strains and their characteristics in the Baise region,encompassing Jingxi City,Napo County,Debao County,and Youjiang District.Methods Participants were selected from newly reported adult patients infected with HIV between 2022 and 2023,and their plasma samples were collected for viral RNA extraction,reverse transcription amplification,sequencing,and determination of HIV-1 subtype and subcluster.Results A total of 257 newly reported HIV/AIDS cases were analyzed.Among these,56.0％were aged 50 years and above,65.0％were male,85.2％were farmers,and 84.0％were of Zhuang ethnicity.Illiteracy or primary school education was reported by 51.4％of the patients,and 56.8％were married.Heterosexual transmission accounted for 93.0％of the cases.Eight genetic subtypes were identified,with CRF08_BC(51.0％,131 cases),CRF01_AE(31.1％,80 cases),and CRF07_BC(12.8％,33 cases)being the predominant strains.The distribution of these subtypes varied significantly across age groups,demographics,transmission routes,and residential areas(all P＜0.05).The three main strains clustered into six larger subclusters and 12 smaller subclusters.Sequences from Youjiang District predominantly clustered into three major subclusters(CRF08_BC subclusters 1 and 5,and a new CRF01_AE subcluster 3).The Jingxi City sequences formed one major subcluster(CRF08_BC subcluster 8),while the Debao County sequences formed one major subcluster(a new CRF01_AE subcluster 1).One large subcluster(CRF07_BC subcluster 2)exhibited no regional clustering.Conclusions HIV-1 epidemic strains in the China-Vietnam border area of Baise from 2022 to 2023 exhibited complexity and diversity.However,CRF08_BC,CRF01_AE,and CRF07_BC remained the predominant strains and clustered into multiple distinct subclusters with evident regional characteristics.
万方数据
维普
