The prevalence of immune reconstitution dysfunction following antiretroviral therapy in HIV/AIDS patients:A meta-analysis
Objective To systematically evaluate the prevalence of immune reconstitution dysfunction among HIV/AIDS patients following combination antiretroviral therapy(cART).Methods A comprehensive literature search was conducted across databases,including China National Knowledge Infrastructure(CNKI),VIP Chinese Journal Service Platform,Wanfang Data Knowledge Service Platform,the Chinese Biomedical Literature Database,PubMed,Embase,Web of Science,and the Cochrane Library.The search encompassed publications addressing the prevalence of immune reconstitution dysfunction among HIV/AIDS patients undergoing cART,from inception of each database until April 2024.A meta-analysis was performed using Stata 14.0 software.Results A total of 39 studies were included,comprising 29 458 participants,of whom 6 735 exhibited immune reconstitution dysfunction.The meta-analysis revealed an overall prevalence of immune reconstitution dysfunction of 24.3％(95％CI:19.3-29.7)among HIV/AIDS patients post cART.In China,the prevalence was 28.4％(95％CI:20.6-37.0).Subgroup analysis revealed higher prevalence among males,individuals from Asia,those infected via blood transmission,patients receiving cART for s2 years,individuals with baseline CD4 counts＜200 cells/μL,baseline viral loads ≥1×105 copies/mL,and patients co-infected with HBV or HCV.Conclusions Current evidence suggests a relatively high prevalence of immune reconstitution dysfunction following cART among patients with HIV/AIDS,with variations observed across patient characteristics.Close monitoring,follow-up,and tailored interventions are essential to facilitate optimal immune recovery in high-risk populations.
万方数据
维普
