首页|Plant-based dietary patterns and risk of esophageal cancer:A prospective cohort study spanning 17 years
Plant-based dietary patterns and risk of esophageal cancer:A prospective cohort study spanning 17 years
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Objective:Plant-based diets have multiple health benefits for cancers;however,little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation of the prospective associations among three predefined indices of plant-based dietary patterns and the risk of EC.Methods:We performed endoscopic screening for 15,709 participants aged 40-69 years from two high-risk areas of China from January 2005 to December 2009 and followed the cohort until December 31,2022.The overall plant-based diet index(PDI),healthful plant-based diet index(hPDI),and unhealthful plant-based diet index(uPDI),were calculated using survey responses to assess dietary patterns.We applied Cox proportional hazard regression to estimate the multivariable hazard ratios(HRs)and 95％confidence intervals(95％CIs)of EC across 3 plant-based diet indices and further stratified the analysis by subgroups.Results:The final study sample included 15,184 participants in the cohort.During a follow-up of 219,365 person-years,176 patients with EC were identified.When the highest quartile was compared with the lowest quartile,the pooled multivariable-adjusted HR of EC was 0.50(95％CI,0.32-0.77)for hPDI.In addition,the HR per 10-point increase in the hPDI score was 0.42(95％CI,0.27-0.66)for ECs.Conversely,uPDI was positively associated with the risk of EC,and the HR was 1.80(95％CI,1.16-2.82).The HR per 10-point increase in the uPDI score was 1.90(95％CI,1.26-2.88)for ECs.The associations between these scores and the risk of EC were consistent in most subgroups.These results remained robust in sensitivity analyses.Conclusions:A healthy plant-based dietary pattern was associated with a reduced risk of EC.Emphasizing the healthiness and quality of plant-based diets may be important for preventing the development of EC.
Esophageal cancerdietdietary patternepidemiologynutritionprospective cohort study
Department of Epidemiology and Health Statistics,School of Public Health,Beijing Municipal Key Laboratory of Clinical Epidemiology,Capital Medical University,Beijing 100069,China
National Central Cancer Registry office,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
Department of Cancer Epidemiology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
Beijing Nova ProgramCAMS Innovation Fund for Medical Sciences(CIFMS)CAMS Innovation Fund for Medical Sciences(CIFMS)Talent Incentive Program of Cancer Hospital Chinese Academy of Medical Sciences(Hope Star)
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