首页|Immune status and combined immunotherapy progression in Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors

Immune status and combined immunotherapy progression in Kirsten rat sarcoma viral oncogene homolog(KRAS)-mutant tumors

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Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most frequently mutated oncogene,occurring in various tumor types.Despite extensive efforts over the past 40 years to develop inhibitors targeting KRAS mutations,resistance to these inhibitors has eventually emerged.A more precise understanding of KRAS mutations and the mechanism of resistance development is essential for creating novel inhibitors that target specifically KRAS mutations and can delay or overcome resistance.Immunotherapy has developed rapidly in recent years,and in-depth dissection of the tumor immune microenvironment has led researchers to shift their focus to patients with KRAS mutations,finding that immune factors play an essential role in KRAS-mutant(KRAS-Mut)tumor therapy and targeted drug resistance.Breakthroughs and transitions from targeted therapy to immunotherapy have provided new hope for treating refractory patients.Here,we reviewed KRAS mutation-targeted treatment strategies and resistance issues,focusing on our in-depth exploration of the specific immune status of patients with KRAS mutations and the impact of body immunity following KRAS inhibition.We aimed to guide innovative approaches combining RAS inhibition with immunotherapy,review advances in preclinical and clinical stages,and discuss challenges and future directions.

CancerKRAS mutationtargeted therapyimmunotherapyimmune microenvironment

Dongsheng He、Rilan Bai、Naifei Chen、Jiuwei Cui

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Cancer Center,the First Hospital of Jilin University,Changchun 130021,China

National Natural Science Foundation of China-Youth Fund ProjectJilin Provincial Science and Technology DepartmentJilin Provincial Science and Technology DepartmentJilin Provincial Development and Reform CommissionChangchun Science and Technology Bureau

3200061720200602032ZP20210303002SF2021C1021ZGY28

2024

10.21147/j.issn.1000-9604.2024.04.06

中国癌症研究(英文版)
中国抗癌协会 北京市肿瘤研究所

中国癌症研究(英文版)

CSTPCD
影响因子：1.592
ISSN：1000-9604
年,卷(期)：2024.36(4)