Molecular transmission network characteristics of HIV-1 subtypes B,CRF01_AE and C in newly reported human immunodeficiency virus infections in Dehong Dai and Jingpo Autonomous Prefecture during 2018-2019
Objective To analyze the characteristics of molecular transmission network of HIV-1 subtypes B,CRF01_AE and C among newly reported HIV-infected patients in Dehong Dai and Jingpo Autonomous Prefec-ture(Dehong prefecture)from 2018 to 2019,and provide scientific support for precise HIV prevention and con-trol.Methods Data on newly reported HIV-infected patients in Dehong prefecture from 2018 to 2019 were ob-tained from the national comprehensive HIV/AIDS prevention and control information system and the demographic characteristics of newly reported HIV infections were analyzed.Peripheral blood samples containing more than 200 μl plasma from HIV-infected patients were selected for amplification,sequencing,splicing,alignment and typing of the HIV pol gene.Mega 7.0 and Gephi 0.10.1 software were used for constructing molecular transmission network.Results There were 300(33.3％)Chinese and 600(66.7％)Burmese HIV infections in newly reported HIV-infected patients in Dehong prefecture from 2018 to 2019.There were statistically significant difference in distribution of age,marriage、nation,education level,infection route,gene subtype,reporting location,contact history between Chinese and Burmese patients.Univariate logistic regression analysis showed that Burmese patients were 6.855 times more likely than Chinese patients to contract HIV by injecting drug use(OR=6.855,95％CI:4.075-11.531).In ad-dition,according to analysis of the molecular transmission network of HIV-1 subtypes B,CRF01_AE and C,the mo-lecular transmission network of HIV-1 subtype B had an active HIV transmission cluster that was independent of the main transmission cluster(large cluster),and this cluster tended to expand continuously.HIV infections in this cluster were all Burmese male under 35 years old,concentrated in Longchuan and Yingjiang counties,and their gender,age and educa-tion level were homogenous.Conclusions Among HIV-1 infections in Dehong prefecture,burmese infections with subtype B formed a distinct active transmission cluster,demonstrating notable geographic and demographic aggregation characteristics,and displaying an expanding trend.Dehong prefecture should pay more attention to HIV infections in the active HIV transmission network in Longchuan and Yingjiang counties,achieve precise prevention and control and reduce the transmission of AIDS.
Human immunodeficiency virusHuman immunodeficiency virusGene subtypesMolecular transmission networkActive HIV transmission cluster
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NSTL
万方数据
