深圳市126例男男同性性行为者8种疱疹病毒感染的初步研究
Primary investigation on the infection spectrum of eight herpesviruses among 126 men who have sex with men in Shenzhen
叶薇 1胡鹏威 1昌华平 1杨梓杰 2徐仲良 1严燚 1袁建辉1
作者信息
- 1. 深圳市南山区疾病预防控制中心,广东深圳 518054
- 2. 北京大学公共卫生学院全球卫生系,北京 100083;深圳市疾病预防控制中心艾滋病预防控制所,广东深圳 518020
- 折叠
摘要
目的 了解深圳市男男同性性行为人群(men who have sex with men,MSM)八种疱疹病毒(her pes viruses,HHV)携带率,分析深圳市MSM人群HHV感染的危险因素.方法 采用非概率抽样法收集2021年4月—12月在深圳市咨询检测的男性口腔拭子及调查问卷,分为MSM组及对照组,用实时荧光定量核酸扩增技术,对8种HHV DNA进行检测,用Epidata双份录入问卷.对调查对象的人口学信息进行描述性分析,采用x2检验分析其性行为情况和HIV、梅毒、疱疹病毒感染情况,采用logistic回归进行HIV、疱疹病毒感染危险因素分析.结果 共调查250人,其中MSM组126人,对照组124人.MSM组HHV人群中,HSV-1携带率为9.52％(12/126)、HSV-2携带率为2.38％(3/126)、VZV携带率为0、EBV携带率为 37.30％(47/126)、HCMV携带率为 0.79％(1/126)、HHV-6携带率为 19.05％(24/126)、HHV-7携带率为94.44％(119/126)、HHV-8携带率为0.79％(1/126);对照组人群HSV-1携带率为2.42％(3/124)、HSV-2 携带率为 4.03％(5/124)、VZV 携带率为 0、EB 病毒携带率为 20.16％(25/124)、HCMV携带率为 0、HHV-6携带率为 14.52％(18/124)、HHV-7携带率为 95.57％(119/124)、HHV-8携带率为0.MSM组的HSV-1、EB病毒携带率显著高于对照组(x2分别为5.593、8.954;P均＜0.05);灌肠行为(aOR=6.549,95％CI:1.773～24.184)是 HSV-1 感染的危险因素,吸烟(aOR=3.277,95％CI:1.219～8.807)是EB病毒感染的危险因素;未发现其他HHV感染相关危险因素.结论 减少灌肠行为有助于减少HSV-1感染的发生,减少吸烟有助于减少EBV感染的发生.由于MSM人群具有较高的HIV感染风险,会引发较重的HHV疾病负担,虽然MSM组与对照组的6种HHV感染谱总体相近,但有必要加强MSM人群HHV感染的监测和干预.
Abstract
Objective To study the carrying rate of eight herpes viruses(HHV)among men who have sex with men(MSM)in Shenzhen,and to analyze the risk factors of HHV infection among MSM in Shenzhen city.Methods Non-probability sampling method was used to collect oral swabs and questionnaires of MSM group and control group who were counseled and tested from two voluntary counseling and testing(VCT)clinics in Shenzhen from April to December 2021.Eight kinds of HHV DNA were detected by GeneXpert MTB/RIF,then the questionnaires were double recorded using Epidata.The demographic information of the survey subjects was subjected to descriptive analysis.Chi-square testing was used to examine their sexual behavior and the status of HIV,treponemiapallidum and herpes virus infections.Logistic regression was used to analyze the risk factors for HIV and herpes virus infections.Results A total of 250 people were surveyed,including 126 in the MSM group and 124 in the control group.The carrying rates of HHV in the MSM group were HSV-19.52％(12/126),HSV-2 2.38％(3/126),VZV0,EBV 37.30％(47/126),HCMV 0.79％(1/126),HHV-6 19.05％(24/126),HHV-7 94.44％(119/126),HHV-8 0.79％(1/126).The carrying rates of HHV in the control group were HSV-1 2.42％(3/124),HSV-2 4.03％(5/124),VZV 0,EBV 20.16％(25/124),HCMV 0,HHV-614.52％(18/124),HHV-7 95.57％(119/124),HHV-8 0.The carrying rates of HSV-1(x2=5.593,P＜0.05)and EBV(x2=8.954,P＜0.05)in the MSM group were significantly higher than those in the control group.Enema behavior(aOR=6.549,95％CI:1.773-24.184)was a risk factor for HSV-1 infection,and smoking(aOR=3.277,95％CI:1.219-8.807)was a risk factor for EBV infection.There was no significant dif-ference in the risk factors of other HHVs between the MSM group and the control group.Conclusions Reduc-ing enema behavior can help reduce the incidence of HSV-1 infection,and reducing smoking can help reduce the in-cidence of EBV infection.Since they have a higher risk of HIV infection,the MSM population will have a heavier burden of HHV disease.Although the infection spectra of six HHVs are generally similar in the MSM group and the control group,it is necessary to strengthen the monitoring and intervention of HHV infection in MSM.
关键词
男男同性性行为/疱疹病毒/核酸/实时荧光定量核酸扩增技术/人类免疫缺陷病毒Key words
Men who have sex with men/Herpes viruses/Nucleic acid/GeneXpert MTB/RIF/Human immu-nodeficiency virus引用本文复制引用
基金项目
深圳市南山区医学重点学科建设项目()
深圳市南山区技术研发和创意设计项目分项资金教育(卫生)科技项目(NS2021096)
出版年
2024
NETL
NSTL
万方数据