新型冠状病毒灭活疫苗在不同人群中安全性和有效性研究进展
The safety and efficacy of inactivated SARS-CoV-2 vaccine in different populations
张海荣 1随海田 2黄丽芳 1周勇1
作者信息
- 1. 福建省疾病预防控制中心福建省人兽共患病重点实验室福建省预防医学研究院,福建福州 350012
- 2. 中国生物技术股份有限公司,北京 100024
- 折叠
摘要
2019年底暴发的新型冠状病毒感染(coronavirus disease 2019,COVID-19)在全球肆虐,对人类生命、公共医疗保健系统和全球经济造成了严重破坏.新型冠状病毒(新冠病毒)灭活疫苗在全球人群中的广泛接种,证实了其对COVID-19重症和死亡的保护效果.老年人、儿童、孕妇和哺乳期妇女、慢性病人群以及免疫功能受损人群是新冠病毒易感和高危人群,也是新冠病毒疫苗接种犹豫的主要人群.在全球范围内特定人群接种新冠病毒灭活疫苗的安全性和有效性临床研究已有相关报道,本文对新冠病毒灭活疫苗的有效性及其在特定人群中接种的免疫原性和安全性展开综述,为新冠病毒灭活疫苗的接种策略提供参考.
Abstract
The outbreak of coronavirus disease 2019(COVID-19)by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in late 2019 has caused severe damage to human lives,public healthcare systems,and the global economy.Widespread immunization with inactivated SARS-CoV-2 vaccine covers a global population and has demonstrated strong protective efficacy in preventing COVID-19 critical/serious illness and death.The elderly,children,pregnant and lactating women,patients with chronic diseases,and immunocompromised population are susceptible and at high risk for COVID-19.These people are also the major population hesitating to receive vaccine.Sufficient clinical researches on the safety and efficacy of inactivated SARS-CoV-2 vaccine have been reported globally in specifical population.In this review,we summarize the efficacy of inactivated SARS-CoV-2 vaccine and its immunogenicity and safety in specifical population,so as to provide a reference for vaccination strategies of inactivated SARS-CoV-2 vaccine.
关键词
新型冠状病毒/新型冠状病毒感染/灭活疫苗/特定人群/安全性/有效性Key words
SARS-CoV-2/COVID-19/Inactivated SARS-CoV-2 vaccine/Specifical population/Safety/Efficacy引用本文复制引用
基金项目
福建省卫生健康委科技项目(2021RKA007)
出版年
2024
NETL
NSTL
万方数据