Objective To evaluate the clinical value of serum oligosaccharide chain(G-Test)detection in assist-ing the diagnosis of hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).Methods A total of 1 100 samples were collected from Jiangsu Province Hospital,Beijing Youan Hospital,and Tianjin Second People's Hospital during February 2017 and August 2018,including 170 healthy controls,310 chronic hepatitis B,180 hepatitis B-related cirrhosis,80 other solid organ malignancies,and 360 HBV-related HCC patients.The relative concentration of oligosaccharide chain components in serum was detected by the G-Test kit.The sensitivity,specificity,total coincidence rate,positive predictive value,and negative predictive value of the de-tection results in clinical diagnosis were calculated and analyzed by the XSD-HCC model.SPSS 19.0 software was used for statistical analysis of the sensitivity,specificity,overall concordance rate,and Kappa value of the kit.The G-Test detection results were expressed with a 95％confidence interval,and receiver operating charac-teristic(ROC)curve analysis was performed.Results The G-Test had good sensitivity(83.61％),specificity(87.84％),and total coincidence rate(86.45％)in the diagnosis of HCC,with a positive predictive value of 76.98％and a negative predictive value of 91.68％,demonstrating good diagnostic performance.The detection rate of the G-Test was 85.53％in alpha-fetoprotein(AFP)-negative HCC and the sensitivity of the G-Test was 90.17％in combination with AFP.Conclusions The sensitivity and specificity of G-Test is good,and it has clinical application value in assisting the diagnosis of HCC.The good clinical performance of G-Test in AFP-negative HCC can increase the detection rate of AFP-negative HCC.
关键词
乙型肝炎病毒/肝细胞癌/寡糖链/甲胎蛋白/G-Test
Key words
Hepatitis B virus/Hepatocellular carcinoma/Oligosaccharide chain/Alpha-fetoprotein/Serum oligosac-charide chain(G-Test)
维普
万方数据