Glycosylation is one of the post-translational modifications with the most diverse functions in living organisms.Core fucose(CF)is a common glycoform of N-glycans which is catalytically regulated by α-1,6 fucosyltransferase.Researches in recent years have shown that CF plays an important role in the development and progression of tumors and other diseases.Challenges from low glycoprotein abundance,microheterogeneity of glycan chains,and detection techniques such as mass spectrometry have posed great challenges to the discovery of CF-modified proteins and application studies.This review will introduce the biosynthesis and regulatory mechanism of protein CF modification,and its roles in the regulation of physiopathological processes,with the expectation to provide insights for the discovery and clinical application of CF-modified proteins.
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