HIV感染相关脏器损伤生物标志物研究进展

Research progress on biomarkers of multiple organ damage associated with HIV infection

王晓昌 ¹张子丽 ¹卢文菊 ¹唐小平²

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作者信息

1. 呼吸疾病全国重点实验室广州呼吸健康研究院广州医科大学附属第一医院广州医科大学,广东广州 510180
2. 广州医科大学,广东广州 510060
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摘要

艾滋病是一种全球流行的传染病.人体感染人类免疫缺陷病毒(human immunodeficiency virus,HIV)后会经历多个发展阶段,针对不同的阶段研究者已经发现和证实了多种生物标志物,这些标志物的检测广泛应用于临床HIV感染及艾滋病的诊疗,极大遏制了病毒的传播,改善了疾病的预后.然而,HIV感染者常伴有多个脏器或系统不同程度的损伤,相应出现了更多更复杂的生物标志物,这便增加了艾滋病治疗的难度.因此,本文旨在对近年来HIV感染相关脏器损伤生物标志物的研究进展进行综述,针对生物标志物的多样性和复杂性所带来的挑战提出解决方案和思路,以期为艾滋病治疗的个体化、精准化及预后评估提供新的线索和依据.

Abstract

Acquired immunodeficiency syndrome(AIDS)is a globally prevalent infectious disease.The human body will undergo multiple stages of disease progression after human immunodeficiency virus(HIV)infection,and a variety of biomarkers have been identified and confirmed for different stages.These biomarkers are widely used in the clinical diagnosis and treatment of HIV infection and AIDS,significantly curbing the spread of the virus and im-proving the prognosis of the disease.However,HIV-infected individuals often experience varying degrees of damage to multiple organs or systems,leading to a more complex array of biomarkers that complicate treatment strategies.Therefore,this paper aims to review the research progress of biomarkers related to organ damage in HIV infection,addressing the challenges brought by the diversity and complexity of these biomarkers,with a view to providing potential solutions and insights to enhance personalized and precision treatment approaches,as well as prognostic assessment for AIDS.

关键词

人类免疫缺陷病毒(HIV)/艾滋病(AIDS)/脏器损伤/生物标志物

Key words

Human immunodeficiency virus/Acquired immunodeficiency syndrome/Organ damage/Biomarkers

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基金项目

国家自然科学基金(82241026)

出版年

2024

中国病毒病杂志

CSTPCD

影响因子：0.734

ISSN：

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