Live attenuated vaccines can effectively mimic the natural infection pathways of viruses,eliciting robust immune responses.Traditional attenuation methods for developing viral vaccines are time-consuming and carry the risk of reversion to virulence.However,the rapid advancements in modern molecular biology and bioinformatics have provided important support for the rapid research and development of novel live attenuated vaccines.This paper reviews the recent progress and applications in virus attenuation techniques and strategies,providing insights into the design and development of novel attenuated vaccines.
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