首页|Cross-sectional Seroprevalence and Genotype of Hepatitis E Virus in Humans and Swine in a High-density Pig-farming Area in Central China

Cross-sectional Seroprevalence and Genotype of Hepatitis E Virus in Humans and Swine in a High-density Pig-farming Area in Central China

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Hepatitis E virus (HEV) infection is a common public health problem in developing countries.However,the current prevalence of HEV and the relationship of HEV genotype between swine and human within high-density pig-farming areas in central China are still inadequately understood.Here,cross-sectional serological and genotypic surveys of HEV among the 1232 general population,273 workers occupationally exposed to swine,and 276 pigs in a high-density pig-breeding area,were undertaken by ELISA and nested RT-PCR methods.Anti-HEV IgG was detected in 26.22％ of general population and 48.35％ of occupational workers.The prevalence of swine serum HEV-Ag was 6.52％.The prevalence of anti-HEV IgG was significantly higher among the workers occupationally exposed to swine than among the general population.An increased HEV seropositivity risk among the general population was associated with either being a peasant or male and was very strongly associated with the increase of age.Among the occupationally exposed group,the prevalence of anti-HEV IgG antibodies increased with age and working years.Among the 30 HEV-IgM-positive people,the infection rates of clerks in the public,peasants,pork retailers,and pig farmers were higher than those of others.A phylogenetic analysis revealed that all the isolates belonged to subgenotype 4d,and four people and four pigs shared 97.04％-100％ sequence homology.This study revealed a high HEV seroprevalence among the general population and workers occupationally exposed to swine in the Anlu City,and supports the notion that swine are a source of human HEV infection.

Hepatitis E virus (HEV)Seroepidemiological studyZoonosisCross-sectional studyGenotype

Yilin Shu、Yameng Chen、Sheng Zhou、Shoude Zhang、Qin Wan、Changcai Zhu、Zhijiang Zhang、Hailong Wu、Jianbo Zhan、Ling Zhang

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College of Life Sciences, Anhui Normal University,Wuhu 421000, China

Anlu Center for Disease Control and Prevention,Anlu 432600, China

School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China

Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China

Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan 430071, China

Division for Viral Disease with Detection, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430065,China

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supported by General Projects of Health and Family Planning Commission of Hubei Province of Chinasupported by General Projects of Health and Family Planning Commission of Hubei Province of Chinasupported by General Projects of Health and Family Planning Commission of Hubei Province of Chinaand Occupational Hazard and Identification Control of Hubei Provincial Key Laboratory Open Fund

no.WJ2017M174WJ2017M240no.OCHI2017G02

2019

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCDSCI
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2019.34(4)
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