Abstract
Influenza A virus(IAV)genome comprises eight negative-sense RNA segments,of which the replication is well orchestrated and the delicate balance of multiple segments are dynamically regulated throughout IAV life cycle.However,previous studies seldom discuss these balances except for functional hemagglutinin-neuraminidase balance that is pivotal for both virus entry and release.Therefore,we attempt to revisit IAV life cycle by high-lighting the critical role of"genome balance".Moreover,we raise a"balance regression"model of IAV evolution that the virus evolves to rebalance its genome after reassortment or interspecies transmission,and direct a"balance compensation"strategy to rectify the"genome imbalance"as a result of artificial modifications during creation of recombinant IAVs.This review not only improves our understanding of IAV life cycle,but also fa-cilitates both basic and applied research of IAV in future.
基金项目
National Natural Science Foundation of China(82104134)
Key Technology Research and Development Program of Shandong,China(2020CXGC010505)
Social Benefiting Technology Program of Qingdao,China(21-1-4-rkjk-15-nsh)
国家科技期刊平台
NSTL
万方数据