首页|Revisiting influenza A virus life cycle from a perspective of genome balance

Revisiting influenza A virus life cycle from a perspective of genome balance

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Influenza A virus(IAV)genome comprises eight negative-sense RNA segments,of which the replication is well orchestrated and the delicate balance of multiple segments are dynamically regulated throughout IAV life cycle.However,previous studies seldom discuss these balances except for functional hemagglutinin-neuraminidase balance that is pivotal for both virus entry and release.Therefore,we attempt to revisit IAV life cycle by high-lighting the critical role of"genome balance".Moreover,we raise a"balance regression"model of IAV evolution that the virus evolves to rebalance its genome after reassortment or interspecies transmission,and direct a"balance compensation"strategy to rectify the"genome imbalance"as a result of artificial modifications during creation of recombinant IAVs.This review not only improves our understanding of IAV life cycle,but also fa-cilitates both basic and applied research of IAV in future.

Influenza A virus(IAV)Segmented genomeGenome balanceBalance regressionBalance compensation

Ruikun Du、Qinghua Cui、Zinuo Chen、Xiujuan Zhao、Xiaojing Lin、Lijun Rong

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Innovation Research Institute of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan,250355,China

Qingdao Academy of Chinese Medicinal Sciences,Shandong University of Traditional Chinese Medicine,Qingdao,266122,China

College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China

Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago,Chicago,60612,USA

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National Natural Science Foundation of ChinaKey Technology Research and Development Program of Shandong,ChinaSocial Benefiting Technology Program of Qingdao,China

821041342020CXGC01050521-1-4-rkjk-15-nsh

2023

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD北大核心
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.(1)
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