首页|Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

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Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron variants.Questions concerning about memory B cells(MBCs)and T cells immunity against Omicron variants,features of long-term immunity,after booster and OBI,needs to be explored.Here,comparative analysis demonstrate antibody and T cell immunity against ancestral strain,Delta and Omicron variants in Omicron breakthrough infected patients(OBIPs)are comparable to that in Ad5-nCoV boosted healthy volunteers(HVs),higher than that in inactivated vaccine(InV)boosted HVs.However,memory B cells(MBCs)immunity against Omicron variants was highest in OBIPs,followed by Ad5-nCoV boosted and InV boosted HVs.OBIPs and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs,and lower naive MBCs and atypical MBCs relative to both vaccine boosted HVs.Collectively,these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.

Inactivated vaccine boosterAd5-nCoV boosterOmicron variants breakthrough infectionMemory immunityBinding antibody

Pei Yu、Zijian Liu、Zhuoqi Zhu、Jiaqing Yang、Min Deng、Mingxiao Chen、Changchun Lai、Weiya Kong、Shilong Xiong、Li Wan、Weikang Mai、Lu Chen、Yu Lei、Shahzad Akbar Khan、Jianfeng Ruan、An Kang、Xuguang Guo、Qiang Zhou、Wenrui Li、Zheng Chen、Yuemei Liang、Pingchao Li、Lei Zhang、Tianxing Ji

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Clinical Laboratory Medicine Department,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China

State Key Laboratories of Respiratory Diseases,Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,510535,China

Clinical Laboratory Medicine Department,Dongguan Ninth People's Hospital,Dongguan,523016,China

State Key Laboratory of Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China

Clinical Laboratory Medicine Department Maoming People's Hospital,Maoming 525000,China

Laboratory of Pathology,Department of Pathobiology,University of Poonch Rawalakot Azad Kashmir Pakistan 12350,Pakistan

Hospital Infection-Control Department,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China

Medical Examination Department,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China

Department of Clinical Laboratory Medicine,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,510140,China

Kidney Transplant Department,The Second Affiiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China

Department of Organ Transplantation,The Third Affiliated Hospital of Sun Yat-sen University,510630,China

Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases,KingMed School of Laboratory Medicine,Guangzhou Medical University,Guangzhou,511436,China

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Guangzhou Health Science and Technology ProjectGuangzhou Science and Technology ProjectGuangdong Basic and Applied Basic Research FoundationClinical research project of Guangzhou Medical University Second Affiliated HospitalGuangdong Medical Research FundKey Clinical Specialty of Guangzhou Medical UniversityGuangzhou LaboratoryGuangzhou key discipline of urology

20201A0110782021020100942021A15150125502021-LCYJ-05A20222550F03031EKPG21-30-3

2023

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD北大核心
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.(2)
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