Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Pei Yu ¹Zijian Liu ²Zhuoqi Zhu ³Jiaqing Yang ⁴Min Deng ¹Mingxiao Chen ¹Changchun Lai ⁵Weiya Kong ¹Shilong Xiong ¹Li Wan ¹Weikang Mai ¹Lu Chen ¹Yu Lei ¹Shahzad Akbar Khan ⁶Jianfeng Ruan ⁷An Kang ⁸Xuguang Guo ⁹Qiang Zhou ¹Wenrui Li ³Zheng Chen ¹⁰Yuemei Liang ³Pingchao Li ²Lei Zhang ¹¹Tianxing Ji¹²

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作者信息

1. Clinical Laboratory Medicine Department,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China
2. State Key Laboratories of Respiratory Diseases,Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,510535,China
3. Clinical Laboratory Medicine Department,Dongguan Ninth People's Hospital,Dongguan,523016,China
4. State Key Laboratory of Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou,510120,China
5. Clinical Laboratory Medicine Department Maoming People's Hospital,Maoming 525000,China
6. Laboratory of Pathology,Department of Pathobiology,University of Poonch Rawalakot Azad Kashmir Pakistan 12350,Pakistan
7. Hospital Infection-Control Department,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China
8. Medical Examination Department,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China
9. Department of Clinical Laboratory Medicine,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,510140,China
10. Kidney Transplant Department,The Second Affiiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China
11. Kidney Transplant Department,The Second Affiiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China;Department of Organ Transplantation,The Third Affiliated Hospital of Sun Yat-sen University,510630,China
12. Clinical Laboratory Medicine Department,The Second Affiliated Hospital of Guangzhou Medical University,Guangzhou,510260,China;Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases,KingMed School of Laboratory Medicine,Guangzhou Medical University,Guangzhou,511436,China
折叠

Abstract

Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron variants.Questions concerning about memory B cells(MBCs)and T cells immunity against Omicron variants,features of long-term immunity,after booster and OBI,needs to be explored.Here,comparative analysis demonstrate antibody and T cell immunity against ancestral strain,Delta and Omicron variants in Omicron breakthrough infected patients(OBIPs)are comparable to that in Ad5-nCoV boosted healthy volunteers(HVs),higher than that in inactivated vaccine(InV)boosted HVs.However,memory B cells(MBCs)immunity against Omicron variants was highest in OBIPs,followed by Ad5-nCoV boosted and InV boosted HVs.OBIPs and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs,and lower naive MBCs and atypical MBCs relative to both vaccine boosted HVs.Collectively,these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.

Key words

Inactivated vaccine booster/Ad5-nCoV booster/Omicron variants breakthrough infection/Memory immunity/Binding antibody

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基金项目

Guangzhou Health Science and Technology Project(20201A011078)

Guangzhou Science and Technology Project(202102010094)

Guangdong Basic and Applied Basic Research Foundation(2021A1515012550)

Clinical research project of Guangzhou Medical University Second Affiliated Hospital(2021-LCYJ-05)

Guangdong Medical Research Fund(A2022255)

Key Clinical Specialty of Guangzhou Medical University(0F03031)

Guangzhou Laboratory(EKPG21-30-3)

Guangzhou key discipline of urology()

出版年

2023

中国病毒学

中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD北大核心

影响因子：0.393

ISSN：1674-0769

参考文献量45

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