首页|PLX8394,a RAF inhibitor,inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling

PLX8394,a RAF inhibitor,inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Enterovirus 71(EV71)poses a serious threat to human health,with scattered outbreaks worldwide.There are several vaccines against a few EV71 strains but no efficient drug for the treatment of EV71 infection.Therefore,it is urgent and of significance to develop anti-EV71 drugs.Here,we found that PLX8394,a RAF inhibitor,possesses high antiviral activity against EV71 in vitro,being superior to the traditional clinical drug ribavirin.Moreover,PLX8394 exhibits broad-spectrum antiviral activity against enteroviruses.Notably,in a suckling mouse model,PLX8394 provided a 70％protection rate for EV71-infected mice,reduced the viral load in liver and heart tissues,and relieved the inflammatory response.A mechanistic study showed that PLX8394 inhibited EV71 by sup-pressing the RAF/MEK/ERK signaling pathway.Thus,PLX8394 lays a foundation for the development of new drugs against EV71.

Enterovirus 71(EV71)RAF inhibitorHand,foot,and mouth disease(HFMD)RAF/MEK/ERK signaling PathwayAntiviral agents

Chengyuan Wu、Guangyan Zhu、Fang Qiu、Fuli Ren、Binbin Lin、Dingyu Zhang、Qingyu Yang、Chaolin Huang

展开 >

Wuhan Jinyintan Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,430023,China

State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China

Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,230027,China

National Key Research and Development Plan of ChinaChina Postdoctoral Science FoundationHubei Health Commission

2021YFC23007002021M693363WJ2021M027

2023

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD北大核心
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.(2)
  • 1