中国病毒学2023，Issue(2) ：276-284.

PLX8394,a RAF inhibitor,inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling

Chengyuan Wu Guangyan Zhu Fang Qiu Fuli Ren Binbin Lin Dingyu Zhang Qingyu Yang Chaolin Huang
中国病毒学2023，Issue(2) ：276-284.
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PLX8394,a RAF inhibitor,inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling

Chengyuan Wu 1Guangyan Zhu 1Fang Qiu 1Fuli Ren 2Binbin Lin 3Dingyu Zhang 1Qingyu Yang 1Chaolin Huang1
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作者信息

  • 1. Wuhan Jinyintan Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,430023,China
  • 2. Wuhan Jinyintan Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,430023,China;State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China
  • 3. Wuhan Jinyintan Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,430023,China;Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,230027,China
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Abstract

Enterovirus 71(EV71)poses a serious threat to human health,with scattered outbreaks worldwide.There are several vaccines against a few EV71 strains but no efficient drug for the treatment of EV71 infection.Therefore,it is urgent and of significance to develop anti-EV71 drugs.Here,we found that PLX8394,a RAF inhibitor,possesses high antiviral activity against EV71 in vitro,being superior to the traditional clinical drug ribavirin.Moreover,PLX8394 exhibits broad-spectrum antiviral activity against enteroviruses.Notably,in a suckling mouse model,PLX8394 provided a 70％protection rate for EV71-infected mice,reduced the viral load in liver and heart tissues,and relieved the inflammatory response.A mechanistic study showed that PLX8394 inhibited EV71 by sup-pressing the RAF/MEK/ERK signaling pathway.Thus,PLX8394 lays a foundation for the development of new drugs against EV71.

Key words

Enterovirus 71(EV71)/RAF inhibitor/Hand,foot,and mouth disease(HFMD)/RAF/MEK/ERK signaling Pathway/Antiviral agents

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基金项目

National Key Research and Development Plan of China(2021YFC2300700)

China Postdoctoral Science Foundation(2021M693363)

Hubei Health Commission(WJ2021M027)

出版年

2023
中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD北大核心
影响因子：0.393
ISSN：1674-0769
参考文献量1
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