首页|Prevalence,variation,and transmission patterns of human respiratory syncytial virus from pediatric patients in Hubei,China during 2020-2021

Prevalence,variation,and transmission patterns of human respiratory syncytial virus from pediatric patients in Hubei,China during 2020-2021

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Human respiratory syncytial virus(RSV)is a severe threat to children and a main cause of acute lower respiratory tract infections.Nevertheless,the intra-host evolution and inter-regional diffusion of RSV are little known.In this study,we performed a systematic surveillance in hospitalized children in Hubei during 2020-2021,in which 106 RSV-positive samples were detected both clinically and by metagenomic next generation sequencing(mNGS).RSV-A and RSV-B groups co-circulated during surveillance with RSV-B being predominant.About 46 high-quality genomes were used for further analyses.A total of 163 intra-host nucleotide variation(iSNV)sites distributed in 34 samples were detected,and glycoprotein(G)gene was the most enriched gene for iSNVs,with non-synonymous substitutions more than synonymous substitutions.Evolutionary dynamic analysis showed that the evolutionary rates of G and NS2 genes were higher,and the population size of RSV groups changed over time.We also found evidences of inter-regional diffusion from Europe and Oceania to Hubei for RSV-A and RSV-B,respectively.This study highlighted the intra-host and inter-host evolution of RSV,and provided some evi-dences for understanding the evolution of RSV.

Respiratory syncytial virus(RSV)Intra-host single nucleotide variation(iSNV)Evolutionary dynamicInter-regional diffusion

Yi Yan、Decheng Wang、Ying Li、Zhiyong Wu、Haizhou Liu、Yue Shi、Xiaoxia Lu、Di Liu

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CAS Key Laboratory of Special Pathogens and Biosafety,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,430071,China

National Virus Resource Center,Chinese Academy of Sciences,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Wuhan,430071,China

Computational Virology Group,Center for Bacteria and Viruses Resources and Bioinformation,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan,430071,China

University of Chinese Academy of Sciences,Be

Department of Respiratory Medicine,Wuhan Children' Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430014,China

Pediatric Respiratory Disease Laboratory,Institute of Maternal and Child Health,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430014,China

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National Key Research and Development Program of ChinaNational Natural Science Foundation of ChinaKnowledge Innovation Program of Wuhan-Basi ResearchHealth Commission of Hubei ProvinceNatural Science Fund of Hubei Province

2018YFC1603803319705482022020801010519WJ 2021M2622021CFA012

2023

10.1016/j.virs.2023.05.001

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.38(3)
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