首页|Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport(ESCRT)protein

Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport(ESCRT)protein

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Human immunodeficiency virus-1(HIV-1)encodes simply 15 proteins and thus depends on multiple host cellular factors for virus reproduction.Spastin,a microtubule severing protein,is an identified HIV-1 dependency factor,but the mechanism regulating HIV-1 is unclear.Here,the study showed that knockdown of spastin inhibited the production of the intracellular HIV-1 Gag protein and new virions through enhancing Gag lysosomal degradation.Further investigation showed that increased sodium tolerance 1(IST1),the subunit of endosomal sorting complex required for transport(ESCRT),could interact with the MIT domain of spastin to regulate the intracellular Gag production.In summary,spastin is required for HIV-1 replication,while spastin-IST1 interaction facilitates virus production by regulating HIV-1 Gag intracellular trafficking and degradation.Spastin may serve as new target for HIV-1 prophylactic and therapy.

HIV-1 replicationSpastinGag productionLysosomal degradationEndosomal sorting complex required fortransport(ESCRT)

Wenyuan Shen、Chang Liu、Yue Hu、Qian Ding、Jiabin Feng、Zhou Liu、Xiaohong Kong

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Laboratory of Medical Molecular Virology,School of Medicine,Nankai University,Tianjin,300071,China

Department of Spine Surgery,The Second Hospital of Shandong University,Cheeloo College of Medicine,Shandong University,Jinan,250033,China

International Science and Technology Cooperation Base of Spinal Cord Injury,Tianjin Key Laboratory of Spine and Spinal Cord Injury,Tianjin Medical University General Hospital,Tianjin,300052,China

Department of Infectious Diseases,Tianjin Second People's Hospital,Tianjin,300192,China

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National Natural Science Foundation of ChinaNatural Science Foundation of Tianjin Municipal Science and Technology CommissionNatural Science Foundation of Tianjin Municipal Science and Technology Commission

8157198720JCQNJC0175021JCQNJC01600

2023

10.1016/j.virs.2023.05.006

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.38(3)
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