首页|SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

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A key question in the coronavirus disease 2019(COVID-19)pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)post primary infection,which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus.Here,we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals(CIs)that were among the first to be infected worldwide and without any possible antigen re-exposure since then.The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs.The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82％and 76％,respectively,over the time period of ten months after infection.Accordingly,the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75％of CIs during the follow-up.Collectively,we provide a comprehensive characterization of the long-term memory T cell response in CIs,suggesting that robust SARS-CoV-2-specific T cell immunity post pri-mary infection may be less durable than previously expected.

COVID-19SARS-CoV-2T cell responseConvalescence

Ziwei Li、Tiandan Xiang、Boyun Liang、Jing Liu、Hui Deng、Xuecheng Yang、Hua Wang、Xuemei Feng、Gennadiy Zelinskyy、Mirko Trilling、Kathrin Sutter、Mengji Lu、Ulf Dittmer、Baoju Wang、Dongliang Yang、Xin Zheng、Jia Liu

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Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China

Joint International Laboratory of Infection and Immunity,Huazhong University of Science and Technology,Wuhan,430022,China

Institute for Virology,University Hospital of Essen,University of Duisburg-Essen,Essen,45147,Germany

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesNational Science and Technology Major ProjectNational Science and Technology Major ProjectNational Science and Technology Major ProjectNational Science and Technology Major ProjectDeutsche ForschungsgemeinschaftDeutsche ForschungsgemeinschaftDeutsche ForschungsgemeinschaftMedical Faculty of the University of Duisburg-Essen and Stiftung Universi?tsmedizin,University Hospital Essen,GermanyTongji-Rongcheng Center for Biomedicine,Huazhong University of Science and Technology

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2023

10.1016/j.virs.2023.06.011

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.38(4)
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