中国病毒学2023，Vol.38Issue(4) ：606-619.DOI:10.1016/j.virs.2023.06.011

SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

Ziwei Li Tiandan Xiang Boyun Liang Jing Liu Hui Deng Xuecheng Yang Hua Wang Xuemei Feng Gennadiy Zelinskyy Mirko Trilling Kathrin Sutter Mengji Lu Ulf Dittmer Baoju Wang Dongliang Yang Xin Zheng Jia Liu
中国病毒学2023，Vol.38Issue(4) ：606-619.DOI:10.1016/j.virs.2023.06.011
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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

Ziwei Li 1Tiandan Xiang 1Boyun Liang 1Jing Liu 1Hui Deng 1Xuecheng Yang 1Hua Wang 2Xuemei Feng 1Gennadiy Zelinskyy 3Mirko Trilling 3Kathrin Sutter 3Mengji Lu 3Ulf Dittmer 3Baoju Wang 1Dongliang Yang 1Xin Zheng 1Jia Liu1
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作者信息

  • 1. Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China;Joint International Laboratory of Infection and Immunity,Huazhong University of Science and Technology,Wuhan,430022,China
  • 2. Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China
  • 3. Institute for Virology,University Hospital of Essen,University of Duisburg-Essen,Essen,45147,Germany;Joint International Laboratory of Infection and Immunity,Huazhong University of Science and Technology,Wuhan,430022,China
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Abstract

A key question in the coronavirus disease 2019(COVID-19)pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)post primary infection,which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus.Here,we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals(CIs)that were among the first to be infected worldwide and without any possible antigen re-exposure since then.The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs.The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82％and 76％,respectively,over the time period of ten months after infection.Accordingly,the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75％of CIs during the follow-up.Collectively,we provide a comprehensive characterization of the long-term memory T cell response in CIs,suggesting that robust SARS-CoV-2-specific T cell immunity post pri-mary infection may be less durable than previously expected.

Key words

COVID-19/SARS-CoV-2/T cell response/Convalescence

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基金项目

National Natural Science Foundation of China(92169105)

National Natural Science Foundation of China(82172256)

National Natural Science Foundation of China(81861138044)

National Natural Science Foundation of China(91742114)

National Natural Science Foundation of China(M-0060)

Fundamental Research Funds for the Central Universities(2020kfyXGYJ028)

Fundamental Research Funds for the Central Universities(2020kfyXGYJ046)

Fundamental Research Funds for the Central Universities(2020kfyXGYJ016)

National Science and Technology Major Project(2017ZX10202203-007-006)

National Science and Technology Major Project(2017ZX10202202-001-009)

National Science and Technology Major Project(2017ZX10202202-002-008)

National Science and Technology Major Project(2017ZX10202201-002-003)

Deutsche Forschungsgemeinschaft(DI 714/22-1)

Deutsche Forschungsgemeinschaft(ZE 893/2-1)

Deutsche Forschungsgemeinschaft(RTG1949/2)

Medical Faculty of the University of Duisburg-Essen and Stiftung Universi?tsmedizin,University Hospital Essen,Germany()

Tongji-Rongcheng Center for Biomedicine,Huazhong University of Science and Technology()

出版年

2023
中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
参考文献量41
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