首页|Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan,a tropical island of China

Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan,a tropical island of China

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The risk of emerging infectious diseases(EID)is increasing globally.More than 60％of EIDs worldwide are caused by animal-borne pathogens.This study aimed to characterize the virome,analyze the phylogenetic evolution,and determine the diversity of rodent-borne viruses in Hainan Province,China.We collected 682 anal and throat samples from rodents,combined them into 28 pools according to their species and location,and processed them for next-generation sequencing and bioinformatics analysis.The diverse viral contigs closely related to mammals were assigned to 22 viral families.Molecular clues of the important rodent-borne viruses were further identified by polymerase chain reaction for phylogenetic analysis and annotation of genetic characteristics such as arena-virus,coronavirus,astrovirus,pestivirus,parvovirus,and papillomavirus.We identified pestivirus and bocavirus in Leopoldoms edwardsi from Huangjinjiaoling,and bocavirus in Rattus andamanensis from the national nature reserves of Bangxi with low amino acid identity to known pathogens are proposed as the novel species,and their rodent hosts have not been previously reported to carry these viruses.These results expand our knowledge of viral classification and host range and suggest that there are highly diverse,undiscovered viruses that have evolved independently in their unique wildlife hosts in inaccessible areas.

RodentsViromePhylogenetic analysisNovel virusesWildlife

Youyou Li、Chuanning Tang、Yun Zhang、Zihan Li、Gaoyu Wang、Ruoyan Peng、Yi Huang、Xiaoyuan Hu、Henan Xin、Boxuan Feng、Xuefang Cao、Yongpeng He、Tonglei Guo、Yijun He、Haoxiang Su、Xiuji Cui、Lina Niu、Zhiqiang Wu、Jian Yang、Fan Yang、Gang Lu、Lei Gao、Qi Jin、Meifang Xiao、Feifei Yin、Jiang Du

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Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou,571199,China

Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases,Hainan Medical University,Haikou,571199,China

Department of Pathogen Biology,Hainan Medical University,Haikou,571199,China

NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100005,China

Department of Clinical Laboratory,Center for Laboratory Medicine,Hainan Women and Children's Medical Center,Haikou,571199,China

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Key Research and Development Plan of Hainan ProvinceKey Research and Development Plan of Hainan ProvinceNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaCAMS Innovation Fund for Medical Sciences(CIFMS)CAMS Innovation Fund for Medical Sciences(CIFMS)Major Science and Technology Program of Hainan ProvinceHainan Provincial Natural Science Foundation of ChinaHainan Provincial Natural Science Foundation of ChinaNational Key R&D Program of ChinaScientific Research Foundation of the Higher Education Institutions of Hainan Province,ChinaResearch Project of the Hainan Academician Innovation PlatformHainan Talent Development ProjectGraduate student innovation grant of Hainan Medical UniversityGraduate student innovation grant of Hainan Medical UniversityGraduate student innovation grant of Hainan Medical UniversityGraduate student innovation grant of Hainan Medical University

ZDYF2020150ZDYF2022SHFZ0853206001581860367820603782021-I2M-1-0372021-I2M-1-039ZDKJ202003820RC6282019RC2182022YFE0210300Hnky2021-40YSPTZX202004SRC200003HYYS2020-33Hys2020-360Hys2020-376Qhys2021-356

2023

10.1016/j.virs.2023.08.003

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.38(5)
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