中国病毒学2023，Vol.38Issue(5) ：651-662.DOI:10.1016/j.virs.2023.08.003

Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan,a tropical island of China

Youyou Li Chuanning Tang Yun Zhang Zihan Li Gaoyu Wang Ruoyan Peng Yi Huang Xiaoyuan Hu Henan Xin Boxuan Feng Xuefang Cao Yongpeng He Tonglei Guo Yijun He Haoxiang Su Xiuji Cui Lina Niu Zhiqiang Wu Jian Yang Fan Yang Gang Lu Lei Gao Qi Jin Meifang Xiao Feifei Yin Jiang Du
中国病毒学2023，Vol.38Issue(5) ：651-662.DOI:10.1016/j.virs.2023.08.003
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  • NSTL
  • 万方数据

Diversity and independent evolutionary profiling of rodent-borne viruses in Hainan,a tropical island of China

Youyou Li 1Chuanning Tang 1Yun Zhang 1Zihan Li 1Gaoyu Wang 1Ruoyan Peng 1Yi Huang 1Xiaoyuan Hu 1Henan Xin 2Boxuan Feng 2Xuefang Cao 2Yongpeng He 2Tonglei Guo 2Yijun He 2Haoxiang Su 2Xiuji Cui 1Lina Niu 1Zhiqiang Wu 2Jian Yang 2Fan Yang 2Gang Lu 1Lei Gao 2Qi Jin 2Meifang Xiao 3Feifei Yin 4Jiang Du5
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作者信息

  • 1. Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou,571199,China;Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases,Hainan Medical University,Haikou,571199,China;Department of Pathogen Biology,Hainan Medical University,Haikou,571199,China
  • 2. NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100005,China
  • 3. Department of Clinical Laboratory,Center for Laboratory Medicine,Hainan Women and Children's Medical Center,Haikou,571199,China
  • 4. Department of Clinical Laboratory,Center for Laboratory Medicine,Hainan Women and Children's Medical Center,Haikou,571199,China;Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou,571199,China;Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases,Hainan Medical University,Haikou,571199,China;Department of Pathogen Biology,Hainan Medical University,Haikou,571199,China
  • 5. NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100005,China;Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou,571199,China;Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases,Hainan Medical University,Haikou,571199,China
  • 折叠

Abstract

The risk of emerging infectious diseases(EID)is increasing globally.More than 60％of EIDs worldwide are caused by animal-borne pathogens.This study aimed to characterize the virome,analyze the phylogenetic evolution,and determine the diversity of rodent-borne viruses in Hainan Province,China.We collected 682 anal and throat samples from rodents,combined them into 28 pools according to their species and location,and processed them for next-generation sequencing and bioinformatics analysis.The diverse viral contigs closely related to mammals were assigned to 22 viral families.Molecular clues of the important rodent-borne viruses were further identified by polymerase chain reaction for phylogenetic analysis and annotation of genetic characteristics such as arena-virus,coronavirus,astrovirus,pestivirus,parvovirus,and papillomavirus.We identified pestivirus and bocavirus in Leopoldoms edwardsi from Huangjinjiaoling,and bocavirus in Rattus andamanensis from the national nature reserves of Bangxi with low amino acid identity to known pathogens are proposed as the novel species,and their rodent hosts have not been previously reported to carry these viruses.These results expand our knowledge of viral classification and host range and suggest that there are highly diverse,undiscovered viruses that have evolved independently in their unique wildlife hosts in inaccessible areas.

Key words

Rodents/Virome/Phylogenetic analysis/Novel viruses/Wildlife

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基金项目

Key Research and Development Plan of Hainan Province(ZDYF2020150)

Key Research and Development Plan of Hainan Province(ZDYF2022SHFZ085)

National Natural Science Foundation of China(32060015)

National Natural Science Foundation of China(81860367)

National Natural Science Foundation of China(82060378)

CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-037)

CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-039)

Major Science and Technology Program of Hainan Province(ZDKJ202003)

Hainan Provincial Natural Science Foundation of China(820RC628)

Hainan Provincial Natural Science Foundation of China(2019RC218)

National Key R&D Program of China(2022YFE0210300)

Scientific Research Foundation of the Higher Education Institutions of Hainan Province,China(Hnky2021-40)

Research Project of the Hainan Academician Innovation Platform(YSPTZX202004)

Hainan Talent Development Project(SRC200003)

Graduate student innovation grant of Hainan Medical University(HYYS2020-33)

Graduate student innovation grant of Hainan Medical University(Hys2020-360)

Graduate student innovation grant of Hainan Medical University(Hys2020-376)

Graduate student innovation grant of Hainan Medical University(Qhys2021-356)

出版年

2023
中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
参考文献量50
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