Abstract
Norovirus(NoV)is a major pathogen that causes acute gastroenteritis(AGE)in people of all ages,especially in children.In this study,we investigated the molecular epidemiological characteristics of NoV in children with AGE in Shanghai from 2018 to 2021.The overall detection rate of NoV was 11.9％(181/1545),with annual detection rates of 9.4％(36/381),13.6％(29/213),5.8％(13/226)and 14.2％(103/725),respectively.Of note,the prevalence of NoV in 2020 was significantly lower than that in 2018-2019(10.9％,65/594)(P=0.023)and 2021(14.2％,103/725)(P=0.000).The 181 NoV strains identified in this study were classified into the GⅠ group(1.1％,2/181),GⅡ group(98.3％,178/181)and GⅨ group(0.6％,1/181)according to the VP1 gene.The most common NoV VP1 genotype was GⅡ.4 Sydney_2012(63.5％,115/181),followed by GⅡ.3(19.9％,36/181)and GⅡ.2(9.4％,17/181).For P genotypes,174 strains were sequenced successfully according to the RdRp gene,and the predominant genotype was GⅡ.P16(44.8％,78/174),followed by GⅡ.P31(25.9％,45/174)and GⅡ.P12(21.3％,37/174).Among the 174 cases,GⅡ.4 Sydney_2012[P16](36.8％,64/174)was the dominant genotype,followed by GⅡ.4 Sydney_2012[P31](25.3％,44/174),GⅡ.3[P12](20.1％,35/174)and GⅡ.2[P1 6](8.0％,14/174).In particular,the dominant genotypes in Shanghai changed from GⅡ.4 Sydney_2012[P31]in 2018-2019 to GⅡ.4 Sydney_2012[P16]in 2020-2021.This is the first report to describe the epidemiological changes in NoV infection before and during the COVID-19 pandemic in Shanghai.These data highlight the importance of continuous surveillance for NoV in children with AGE in Shanghai.
基金项目
Key Development Program of the Children's Hospital of Fudan University(EK2022ZX05)
NETL
NSTL
万方数据