首页|Autophagy induced by human adenovirus B7 structural protein Ⅵ inhibits viral replication
Autophagy induced by human adenovirus B7 structural protein Ⅵ inhibits viral replication
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Human adenovirus B7(HAdV-B7)causes severe acute lower respiratory tract infections in children.However,neither the child-specific antivirals or vaccines are available,nor the pathogenesis is clear.Autophagy,as part of innate immunity,plays an important role in resistance to viral infection by degrading the virus and promoting the development of innate and adaptive immunity.This study provided evidence that HAdV-B7 infection induced complete autophagic flux,and the pharmacological induction of autophagy decreased HAdV-B7 replication.In this process,the host protein Bcl2-associated athanogene 3(BAG3)mediated autophagy to inhibit the replication of HAdV-B7 by binding to the PPSY structural domain of viral protein pⅥ through its WW structural domain.These findings further our understanding of the host immune response during viral infection and will help to develop broad anti-HAdV therapies.
Human adenovirus B7(HAdV-B7)AutophagyBcl2-associated athanogene 3(BAG3)Virus replication
Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,100045,China
Research Unit of Critical Infection in Children,2019RU016,Chinese Academy of Medical Sciences,Beijing,100045,China
Department of I
Beijing Coal Gr
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National Natural Science Foundation of ChinaCAMS Innovation Fund for Medical Sciences