中国病毒学2023，Vol.38Issue(5) ：709-722.DOI:10.1016/j.virs.2023.08.002

Autophagy induced by human adenovirus B7 structural protein Ⅵ inhibits viral replication

Linlin Zhang Yali Duan Wei Wang Qi Li Jiao Tian Yun Zhu Ran Wang Zhengde Xie
中国病毒学2023，Vol.38Issue(5) ：709-722.DOI:10.1016/j.virs.2023.08.002
✕
  • NETL
  • NSTL
  • 万方数据

Autophagy induced by human adenovirus B7 structural protein Ⅵ inhibits viral replication

Linlin Zhang 1Yali Duan 2Wei Wang 3Qi Li 1Jiao Tian 1Yun Zhu 1Ran Wang 1Zhengde Xie1
扫码查看

作者信息

  • 1. Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,100045,China;Research Unit of Critical Infection in Children,2019RU016,Chinese Academy of Medical Sciences,Beijing,100045,China
  • 2. Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,100045,China;Research Unit of Critical Infection in Children,2019RU016,Chinese Academy of Medical Sciences,Beijing,100045,China;Department of I
  • 3. Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,100045,China;Research Unit of Critical Infection in Children,2019RU016,Chinese Academy of Medical Sciences,Beijing,100045,China;Beijing Coal Gr
  • 折叠

Abstract

Human adenovirus B7(HAdV-B7)causes severe acute lower respiratory tract infections in children.However,neither the child-specific antivirals or vaccines are available,nor the pathogenesis is clear.Autophagy,as part of innate immunity,plays an important role in resistance to viral infection by degrading the virus and promoting the development of innate and adaptive immunity.This study provided evidence that HAdV-B7 infection induced complete autophagic flux,and the pharmacological induction of autophagy decreased HAdV-B7 replication.In this process,the host protein Bcl2-associated athanogene 3(BAG3)mediated autophagy to inhibit the replication of HAdV-B7 by binding to the PPSY structural domain of viral protein pⅥ through its WW structural domain.These findings further our understanding of the host immune response during viral infection and will help to develop broad anti-HAdV therapies.

Key words

Human adenovirus B7(HAdV-B7)/Autophagy/Bcl2-associated athanogene 3(BAG3)/Virus replication

引用本文复制引用

基金项目

National Natural Science Foundation of China(82072266)

CAMS Innovation Fund for Medical Sciences(2019-I2M-5-026)

出版年

2023
中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
参考文献量39
段落导航相关论文