中国病毒学2023，Vol.38Issue(6) ：851-859.DOI:10.1016/j.virs.2023.10.007

Recent advances in understanding T cell activation and exhaustion during HBV infection

Lu Wang Xiaoqing Zeng Zida Wang Ling Fang Jia Liu
中国病毒学2023，Vol.38Issue(6) ：851-859.DOI:10.1016/j.virs.2023.10.007
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Recent advances in understanding T cell activation and exhaustion during HBV infection

Lu Wang 1Xiaoqing Zeng 2Zida Wang 2Ling Fang 3Jia Liu1
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作者信息

  • 1. Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China;Joint International Laboratory of Infection and Immunity,Huazhong University of Science and Technology,Wuhan,430022,China
  • 2. Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China
  • 3. Central Sterile Supply Department,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China
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Abstract

Chronic hepatitis B virus(HBV)infection remains a major public health concern globally,and T cell responses are widely believed to play a pivotal role in mediating HBV clearance.Accordingly,research on the characteristics of HBV-specific T cell responses,from activation to exhaustion,has advanced rapidly.Here,we summarize recent developments in characterizing T cell immunity in HBV infection by reviewing basic and clinical research pub-lished in the last five years.We provide a comprehensive summary of the mechanisms that induce effective anti-HBV T cell immunity,as well as the latest developments in understanding T cell dysfunction in chronic HBV infection.Furthermore,we briefly discuss current novel treatment strategies aimed at restoring anti-HBV T cell responses.

Key words

Hepatitis B virus(HBV)/T cell/Immune therapy

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基金项目

National Natural Science Foundation of China(82172256)

National Natural Science Foundation of China(92169105)

National Natural Science Foundation of China(81861138044)

National Natural Science Foundation of China(M-0060)

National Scientific and Technological Major Project of China(2017ZX10202203)

Sino-German Virtual Institute for Viral Immunology()

出版年

2023
中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
参考文献量87
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