首页|Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor

Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
Influenza A virus(IAV)poses a global public health concern and remains an imminent threat to human health.Emerging antiviral resistance to the currently approved influenza drugs emphasizes the urgent need for new therapeutic entities against IAV.Allopregnanolone(ALLO)is a natural product that has been approved as an antidepressant drug.In the present study,we repurposed ALLO as a novel inhibitor against IAVs.Mechanistic studies demonstrated that ALLO inhibited virus replication by interfering with the nucleus translocation of viral nucleoprotein(NP).In addition,ALLO showed significant synergistic activity with compound 16,a hemagglutinin inhibitor of IAVs.In summary,we have identified ALLO as a novel influenza virus inhibitor targeting NP,providing a promising candidate that deserves further investigation as a useful anti-influenza strategy in the future.

Allopregnanolone(ALLO)AntiviralInfluenza A virus(IAV)NucleoproteinNucleus translocation

Meiyue Dong、Yanyan Wang、Ping Li、Zinuo Chen、Varada Anirudhan、Qinghua Cui、Lijun Rong、Ruikun Du

展开 >

Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China

College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China

Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago,Chicago,60612,USA

Qingdao Academy of Chinese Medical Sciences,Shandong University of Traditional Chinese Medicine,Qingdao,266122,China

展开 >

National Natural Science Foundation of ChinaNatural Science Foundation of Shandong Province,ChinaMajor Basic Program ofNatural Science Foundation of Shandong ProvinceJinan Independent Training Innovative TeamOpen Research Fund Program of the State Key Laboratory of Virology of China

82104134ZR2020MH383ZR2021ZD172021GXRC0282022IOV003

2023

10.1016/j.virs.2023.09.003

中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
年,卷(期)：2023.38(6)
  • 50