中国病毒学2023，Vol.38Issue(6) ：931-939.DOI:10.1016/j.virs.2023.09.003

Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor

Meiyue Dong Yanyan Wang Ping Li Zinuo Chen Varada Anirudhan Qinghua Cui Lijun Rong Ruikun Du
中国病毒学2023，Vol.38Issue(6) ：931-939.DOI:10.1016/j.virs.2023.09.003
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Allopregnanolone targets nucleoprotein as a novel influenza virus inhibitor

Meiyue Dong 1Yanyan Wang 2Ping Li 2Zinuo Chen 1Varada Anirudhan 3Qinghua Cui 4Lijun Rong 3Ruikun Du4
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作者信息

  • 1. Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China
  • 2. College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China
  • 3. Department of Microbiology and Immunology,College of Medicine,University of Illinois at Chicago,Chicago,60612,USA
  • 4. Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan,250355,China;Qingdao Academy of Chinese Medical Sciences,Shandong University of Traditional Chinese Medicine,Qingdao,266122,China
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Abstract

Influenza A virus(IAV)poses a global public health concern and remains an imminent threat to human health.Emerging antiviral resistance to the currently approved influenza drugs emphasizes the urgent need for new therapeutic entities against IAV.Allopregnanolone(ALLO)is a natural product that has been approved as an antidepressant drug.In the present study,we repurposed ALLO as a novel inhibitor against IAVs.Mechanistic studies demonstrated that ALLO inhibited virus replication by interfering with the nucleus translocation of viral nucleoprotein(NP).In addition,ALLO showed significant synergistic activity with compound 16,a hemagglutinin inhibitor of IAVs.In summary,we have identified ALLO as a novel influenza virus inhibitor targeting NP,providing a promising candidate that deserves further investigation as a useful anti-influenza strategy in the future.

Key words

Allopregnanolone(ALLO)/Antiviral/Influenza A virus(IAV)/Nucleoprotein/Nucleus translocation

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基金项目

National Natural Science Foundation of China(82104134)

Natural Science Foundation of Shandong Province,China(ZR2020MH383)

Major Basic Program ofNatural Science Foundation of Shandong Province(ZR2021ZD17)

Jinan Independent Training Innovative Team(2021GXRC028)

Open Research Fund Program of the State Key Laboratory of Virology of China(2022IOV003)

出版年

2023
中国病毒学
中国科学院武汉病毒研究所，中国微生物学会

中国病毒学

CSTPCDCSCD
影响因子：0.393
ISSN：1674-0769
参考文献量50
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