Abstract
Myocardial injury is one of the most common comorbidity in SARS-CoV-2 infected patients,and has poor prognosis.However,the incidence of myocardial injury in patients with SARS-CoV-2 infection has not been sufficiently investigated during the Omicron wave.We conducted a retrospective study of 2690 patients with confirmed SARS-CoV-2 Omicron infection from Tongji Hospital.The results indicated that the myocardial injury accounted for 30.8％of the total patients with SARS-CoV-2 infection and was associated with higher in-hospital mortality than those without injury before and after propensity score matching(PSM)[adjusted hazard ratio(HR),10.61;95％confidence interval(CI),7.76-14.51;P＜0.001;adjusted HR,2.70;95％CI,1.86-3.93;P＜0.001;respectively].Further,the levels of cytokines(IL-1β,IL-6,IL-10,and TNF-α)in patients with myocardial injury were higher than those without injury,and the higher levels of cytokines in the myocardial injury group were associated with increased mortality.Administration of angiotensin-converting enzyme inhibitors or angio-tensin receptor blockers(ACEI/ARB)could significantly reduce the mortality in patients with myocardial injury(adjusted HR,0.52;95％CI,0.38-0.71;P＜0.001).Additionally,the level of angiotensin II increased in patients with SARS-CoV-2 infection was even higher in myocardial injury group compared to those without injury.Collectively,the study summarized the clinical characteristic and outcome of SARS-CoV-2 infected patients with myocardial injury during the Omicron wave in China,and validated the protective role of ACEI/ARB in improving the survival of those with myocardial injury.
基金项目
National Key Research and Development Program of China(2022YFC3400700)
National Natural Science Foundation of China(82241034)
National Natural Science Foundation of China(82370397)
National Natural Science Foundation of China(31971358)
National Natural Science Foundation of China(U22A20266)
National Natural Science Foundation of China(C-0052)
Top-Notch Talent Program of Hubei Province and Tongji Hospital(2021YBJRC005)
Hubei Provincial Key Research and Developmental Program(2022BCA037)
Hubei Provincial Natural Science Foundation of China(2017CFB536)
NETL
NSTL
万方数据