Objective Explore the nursing care of severe hand foot mouth disease in children with viral encephalitis .Methods In our hospital from April 2011 to October 2012 the clinical data and nursing of 152 cases of hospitalized children with hand foot and mouth disease and treatment of viral encephalitis were retrospectively analyzed.Results 152 cases were cured and discharged.Conclusion Through the strict observation condition,early detection of disease changes,timely intervention,care-ful nursing,the progress of the disease control,promote their rehabilitation.