Objective Analysis of observation continuous renal replacement therapy in acute renal failure results ,as well as prognostic factors.Methods Selected 66 cases of severe acute renal failure in patients taking continuous renal replacement therapy .Observation and analysis of the clinical symptoms of patients before and after treatment characteristics,and prognosis.Result 66 patients,40 patients passed the critical stage,26 patients in the acute phase of death.No significant difference between two groups of patient data.Conclusion Continuous renal replacement therapy in severe acute renal failure can help to improve the prognosis ,but the continuous renal re-placement therapy technology still needs further development to improve in order to better improve the prognosis .