Objective To investigate the changes of reproductive function and Hsp 90αgene expression in reproductive system of rat with varicocele .Methods Healthy 32 SD rats were randomly divided into 4 groups:control group and 3 varicocele group(1,3 and 6w after varicocele).Organ index and HSP90αgene expression in testicle were determined.Result At 1 and3w the epididymis index was significantly lower than it in the control;sperm motility rate is significantly lower than the control group at 1,3w and 6w(P<0.05),Sperm deformity and morality rate were significantly higher than the control group at 1 and 3w(P <0.05).Gene expression of HSP 90αin testicle was significantly higher than those in the control group at1,3 and 6w group(P<0.05).Concluis on Varicocele resulted in the damage of reproductive system,and the increased expression of HSP90αgene in testicle.The increased expression of HSP90αgene may protect cells from varicocele damage.
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