Objective On patients with malignant blood disease merging IFI the clinical characteristics of susceptible factors .Methods In our hospital in January 2001 -January 2012 between the clinical data of 80 patients with malignant blood disease merging IFI,pathogenic bacteria species and susceptible factors were retrospec-tively analyzed,and its clinical treatment mainly is divided into three groups ,to compare the clinical curative effect and the number of cases of adverse reactions occurs. Result Malignant blood disease merging IFI susceptible factors mainly has the relationship with the use of antibiotics ,lack of granulocyte,relationship with the illness and the intensity of chemotherapy,etc.Conclusion IFI have become important complication of granulocyte phase lack of hematologic malignancies and the cause of death ,to strengthen the understanding of haematology merge fungus infection and improve the level of diagnosis and treatment are very important .