Purpose Our purpose is to study the effects of early enteral nutrition on severe brain injuries with stress ulcer .Methods 164 patients with severe brain injury were randomly divided into treatment group and control group .Then control group was given a routine therapy for severe brain injury patients and a 2 times per day intravenous injection of a solution prepared by dissolving 40 mg of omeprazole in 100 ml of 0.9% saline solution.The treatment group was all treated with a nasogastric tube soon after the morbidity of the disease within 24 h and was give early enteral nutrition(clear liquid diet +enteral nutritional suspension)within 48 h.Then the dos-age increase day by day in the future.Results The stress ulcer incidence of the treatment group was 9.7% and the death rate was14.6%.While the control group were 28% and 32.9% respectively.An obvious difference was found in these two groups.Conclusion The key to the stress ulcer treatment is an early prevention and giving an early enteral nutrition which can effectively prevent the severe brain injury with stress ulcer and reduce the fatality rate .