Objective To investigate the clinical efficacy of metoprolol and diltiazem application appears repeatedly infarction in patients with acute myocardial in-farction.Methods Myocardial in our hospital from 2012 February to 2013 January were repeated clinical treatment in patients with infarction of sampling ,40 cases of my-ocardial infarction in patients with recurrent cases according to randomly divided into control group and treatment group ,20 patients in each group.Treatment group were treated with metoprolol treatment,the control group using diltiazem treatment.Observation of the efficacy of the two groups.Results The of two groups of patients with my-ocardial infarction repeatedly after treatment, the treatment group after treatment24 h remission in 11 cases(55%),4 cases of recurrence within 1 months of pain(20%), 1 months and 5 cases of congestive heart failure(25%),1 months,11 cases of deaths(55%);the control group treatment after 24h remission in 4 cases(20%),1 months of pain recurrence in 12 cases(60%),1 months and 18 cases of congestive heart failure(90%),1 months,16 cases of deaths(80%).Two groups of patients with myo-cardial infarction repeatedly clinical treatment effect is significant,statistically significant(P<0.05).Conclusion the clinical efficacy in patients with myocardial infarc-tion repeatedly clinical curative effect of metoprolol is better than that of diltiazem treatment ,can avoid myocardial infarction area expanded ,myocardial oxygen consump-tion,ease the pain of patients,is worthy of clinical application.