摘要
目的：了解2013年某教学医院大肠埃希菌的分离情况及对抗生素的耐药状况。方法2013年1月1日至2013年12月31日共收集到某教学医院分离到的大肠埃希菌817株，采用全自动微量稀释法进行药物敏感性试验，试验结果以CLSI2012年版标准判读。结果大肠埃希菌对替加环素、亚胺培南、阿米卡星和哌拉西林/他唑巴坦的敏感率均大于97％；对呋喃妥因和头孢吡肟的敏感率均大于80％；对头孢西丁的敏感率为73．9；对阿莫西林/克拉维酸、氨曲南、妥布霉素、庆大霉素、左旋氧氟沙星、环丙沙星、复方新诺明、头孢曲松、氨苄西林、头孢唑啉的敏感率均低于70％；ESBL 菌株的检出率为42．1％。结论对大肠埃希菌检出的致病菌应根据各个医院具体的耐药监测数据来使用抗生素，以达到最佳的临床治疗效果。
Abstract
Objective To investigate the drug resistance to antibiotics situation of a teaching hospital of Escherichia coli in 2013.Methods A total of 817 isolated strains of Escherichia coli were collected in a teaching hospital from January 1,2013 to 2013 December 31,the drug sensitivity test was carried out using automatic micro dilution method,the test results were analysed according to the 2012 edition of the CLSI standard.Results Escherichia coli to tigecycline,imipenem,Amikacin and pip-eracillin/tazobactam sensitive rates were higher than 97%;the sensitivity rate to nitrofurantoin and cefepime were higher than 80%;the sensitivity rate to cefoxitin was 73.9;the sensitivity rate of amoxicillin/clavulanic acid,ammonia sensitive,tobramycin,gentamicin,levofloxacin,ciprofloxacin,cotrimoxazole,ceftriaxone,ampicillin,ce-fazolin were less than 70%;the detection rate of ESBL strains were 42.1%.Conclusion In order to achieve the best effect of clinical treatment,the antibiotics should be administered according to drug resistance monitoring data of each hospital .
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