Objective:To study the ultrastructure of hepatic lesion induced by antitubercular drugs. Methods:152 healthy adult rats, weighing about 250~300g,half male and half female, were randomly divided into 8 groups and given different drugs. Control group:NS;group H:isoniazid(INH H);group R:rifampicin (RFP R);group Z:pyrazinamide (PZA Z);group HR:INH+RFP;group HZ:INH+PZA;group RZ:RFP+PZA;group HRZ: INH+RFP+PZA. Rats were given 5.5 times adult clinic therapeutic dose by intragastria administration,once per day,for 10 days.The degrees of hepatic lesion were measured by means of pathology, and the effects of INH, RFP and PZA on hepatic tissues were observed. Results:Some mitochondrions in the liver cells dissolve,rough surfaced endoplasmic reticulum degranulation,smooth surfaced endoplasmic reticulum pool dilatation,the fat particles in the cell increase,hepatin particle apparently increase, dropsy appear around the karyons;collagenous fiber between the liver cells hyperplasia. Conclusion:INH, RFP and PZA can lead to the damages of hepatic tissue, especially in the usage of multiple drugs;the degree of hepatic injury is increased with the numbers of drugs used;the toxicity of PZA on liver is greater than that of other antitubercular drugs.
antitubercular drugsTEM/ultrastructureliver injury/diagnostic use
符照康、胡建军、查月芳、吴树结才、WUShu-cai、HUANGLing-hui
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海南省农垦那大医院 571700
河北省胸科医院内科 河北 石家庄 050041
Department of Internal Medicine, Hebei Provincial Chest Hospital, Shijiazhuang 054000
Clinic of Wuhan Recreation Center for Retired Cadres of General Department of Logistics
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