Objective:To investigate the treatment value of interventional ultrasound for hepatobiliary disease. Methods:We retrospectively analyzed 29 hepatobiliary disease patients who were treated with interventional ultrasound in Central Hospital of Shanghai Jiading District during the period of January 1 to December 31,2011. Results:All patients were cured after 1~2 times treatment.The cure rate was 100%. Conclusion:Interventional ultrasound is a minimally invasive, accurate positioning, intuitive, less complications, and low cost technology.