The present study was to investigate the protective effects of catalpol on dopaminergic neurons were exposured to 1-methyl-4-phenylpyridinium (MPP+10uM)after pretreated with catalpol. The effests of catalpol on MPP+-induced oxidative stress in cultured dopaminergic neurons were observed by immunocytochemical staining for tyrosine hydroxylase(TH) and measuring intracellular reactive oxygen species(ROS). The results showed that catalpol increased neurons cellular viability and markedly attenuated MPP+-induced dopaminergic neurons death and reduced the content of ROS. These findings suggest that catalpol may be a candidate chemical for the treatment of oxidative stress-induced neurodegenerative disease.
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