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病毒性脑炎合并心肌炎患儿血清MMP-9和CTn1水平表达及其临床意义

Viral encephalitis combined myocarditis patients serum MMP-9 and CTn1 level expression and its clinical significance

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目的:探讨基质金属蛋白酶-9(MMP-9)联合心肌钙蛋白Ⅰ(CTnI)检测对病毒性脑炎合并心肌炎早期诊断的意义。方法:选择90例符合病毒性脑炎诊断患儿,按有无合并心肌炎情况分为两组,其中病毒性脑炎组50例,合并心肌炎组40例,并选取20例健康体检儿童为对照组。所有受试者均测定血清MMP-9和CTnI水平。结果:病毒性脑炎合并心肌炎和病毒性脑炎组患儿与对照组MMP-9首次测定分别为423.18±99.26、293.23±75.9、118.89±66.87;三组CTnI首次测定为2.73±1.25、0.76±0.53。与对照组相比,病毒性脑炎组和病毒性脑炎合并心肌炎患儿MMP-9、CTnI水平明显升高,p均<0.05,且合并心肌炎者血清MMP-9、CTnI水平亦显著高于病毒性脑炎组(p<0.05)。结论:血清MMP-9联合CTnI检测在病毒性心肌炎的早期诊断中有重要意义。
Objective:To matrix metalloproteinase-9 (MMP- 9) combined with myocardial calcium proteinⅠ (CTnI) detection of viral encephalitis combined myocarditis early diagnosis significance. Methods:Atotal of 90 patients with diagnosis of children with viral encephalitis, according to whether merger myocarditis situation divided into two groups, including viral encephalitis group of fifty cases, combined with myocarditis group and an example, and select twenty cases of healthy check-up children as control group. All respondents were measured serum levels of MMP-9 and CTnI levels. Results:The viral encephalitis combined myocarditis and viral encephalitis group and control group with MMP-9 first measurement were 423.18+/-99.26, 293.23+/-75.9, 118.89 66.87 mm;Three groups of CTnI determination for the first time was 2.73+/-1.25, 0.76+/-0.53. Compared with the control, viral encephalitis group and viral encephalitis combined with myocarditis MMP-9, CTnI levels increased significantly, p<0.05, and the merger myocarditis serum MMP-9, CTnI levels also significantly higher than that of viral encephalitis group (p<0.05). Conclusion:Serum MMP-9 joint CTnI detection in the early diagnosis of viral myocarditis is of important significance.

Viral encephalitisMyocarditisMatrix metalloproteinase-9Myocardial calcium proteinⅠ

曹治梅、陈方基

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莱西市市立医院 山东 莱西 266600

病毒性脑炎 心肌炎 基质金属蛋白酶-9 心肌钙蛋白Ⅰ

2013

中国保健营养(中旬刊)
全国卫生产业企业管理协会

中国保健营养(中旬刊)

ISSN:1004-7484
年,卷(期):2013.(3)
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